Altered mRNA and lncRNA expression profiles in the striated muscle complex of anorectal malformation rats

This RNA-seq study identifies 1408 differentially expressed mRNAs and 472 lncRNAs in the malformed striated muscle complex of ARM rats, revealing dysregulation in muscle development pathways including WNT3 signaling. Findings provide molecular insights into postoperative defecation dysfunction mechanisms in anorectal malformation patients.