Deletion of interleukin enhancer binding factor 2 (ILF2) resulted in defective biliary development and bile flow blockage

Zebrafish knockout study demonstrates that deletion of ILF2 gene causes defective bile duct development and blocked bile flow, mirroring biliary atresia phenotypes. This is the first functional validation of BA-associated copy number variants, establishing ILF2 as a candidate gene in BA pathogenesis with potential diagnostic implications.