Deficiency of receptor-interacting protein kinase 3 (RIPK3) attenuates inflammation and organ injury in neonatal sepsis

Study demonstrates that receptor-interacting protein kinase 3 (RIPK3) drives excessive inflammation in neonatal sepsis. RIPK3-deficient newborn mice showed significantly reduced cytokine levels, lung injury, and organ damage compared to wild-type mice, suggesting RIPK3 as a potential therapeutic target for attenuating sepsis-related inflammation in neonates.