Downregulation of miR-140-5p affects the pathogenesis of HSCR by targeting EGR2

Study identifies downregulation of miR-140-5p as a key factor in Hirschsprung's disease pathogenesis through its targeting of EGR2. Analysis of 32 HSCR patients revealed inverse correlation between miR-140-5p and EGR2 expression, with miR-140-5p knockdown inhibiting neural crest cell migration and proliferation.