Resection margin histology may predict intermediate-term outcomes in children with rectosigmoid Hirschsprung disease

Study of 45 rectosigmoid HSCR patients reveals that resection margin histology—specifically smaller ganglion size and elevated NOS neurons—correlates with decreased quality of life, suggesting the remaining ganglionated bowel may have structural defects affecting long-term function. Findings support the hypothesis that enteric nervous system abnormalities extend beyond the aganglionic segment.