Pan-enteric neuropathy and dysmotility are present in a mouse model of short-segment Hirschsprung disease and may contribute to post-pullthrough morbidity

Study using Ednrb-null mice reveals that enteric nervous system abnormalities and motility defects extend throughout the ganglionated GI tract in Hirschsprung disease, not just the aganglionic segment. These pan-enteric findings may explain persistent gastrointestinal morbidity following corrective pull-through surgery.