Fecal microbiota transplantation by enema reduces intestinal injury in experimental necrotizing enterocolitis

Experimental study in neonatal mice demonstrates that fecal microbiota transplantation administered by enema reduces intestinal inflammation and improves barrier function in necrotizing enterocolitis, while gavage administration worsened outcomes. Findings suggest enema-based FMT may offer a novel therapeutic approach for this devastating neonatal condition.