SALL4 is a useful marker for pediatric yolk sac tumors

Study demonstrates SALL4 as a highly sensitive immunohistochemical marker for pediatric yolk sac tumors, showing 100% positivity across 22 cases and outperforming traditional markers AFP and Glypican-3. SALL4 effectively distinguishes yolk sac tumors from mature teratomas, establishing it as a valuable diagnostic tool in pediatric germ cell pathology.