Physiologically based cord clamping improves cardiopulmonary haemodynamics in lambs with a diaphragmatic hernia.

This lamb model study demonstrates that physiologically based cord clamping (PBCC)—ventilating the lungs before cutting the umbilical cord—significantly improves pulmonary blood flow and cardiopulmonary transition in congenital diaphragmatic hernia compared to immediate cord clamping, with 19-fold greater pulmonary perfusion at the time of cord separation.