An Overview of Systematic Reviews of Randomized-Controlled Trials for Preventing Necrotizing Enterocolitis in Preterm Infants.

Umbrella review of 98 meta-analyses examining interventions to prevent necrotizing enterocolitis in preterm infants. Moderate-certainty evidence supports probiotics, antenatal corticosteroids, and ibuprofen over indomethacin for PDA treatment in reducing NEC risk, while lower oxygen saturation targets may increase surgical NEC risk.