Accuracy of Suction Rectal Biopsy for Diagnosis of Hirschsprung's Disease in Neonates

Study of 153 infants demonstrates suction rectal biopsy achieves 100% sensitivity and specificity for Hirschsprung disease diagnosis across all age groups including preterm neonates, with adequate tissue obtained on first attempt in 96% of cases and no complications even in infants under 2,500g.