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Vasoactive intestinal peptide decreases inflammation and tight junction disruption in experimental necrotizing enterocolitis

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Topic overview

This murine study demonstrates that exogenous vasoactive intestinal peptide (VIP) administration reduces NEC severity by decreasing inflammatory markers (IL-6, TNF-α) and preserving tight junction integrity (Claudin-3). The findings suggest VIP may offer therapeutic benefit in neonatal NEC by mitigating intestinal barrier disruption.

Keywords

Necrotizing Enterocolitis Vasoactive Intestinal Peptide Intestinal Barrier Function Neonatal Gastroenterology Tight Junction Proteins Anti-inflammatory Therapy Pediatric Surgery

Hashtags

#NecrotizingEnterocolitis #NeonatalGastroenterology #IntestinalBarrier #PediatricSurgery

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How to cite: GlobalCastMD. Vasoactive intestinal peptide decreases inflammation and tight junction disruption in experimental necrotizing enterocolitis. GlobalCastMD Medical Library. 2019-10-23. https://library.globalcastmd.com/article/1745

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