An intra-amniotic injection of mesenchymal stem cells promotes lung maturity in a rat congenital diaphragmatic hernia model

Intra-amniotic injection of human mesenchymal stem cells in a rat CDH model significantly improved lung maturity markers including alveolar structure, septal development, and pulmonary arterial wall thickness. Results demonstrate therapeutic potential for prenatal stem cell intervention in CDH-associated pulmonary hypoplasia.