Endothelin receptor B affects the perfusion of newborn intestine: possible mechanism of necrotizing enterocolitis development

Study demonstrates that partial knockout of endothelin receptor B (EDNRB) in mice reduces NEC severity and tissue hypoxia, suggesting EDNRB plays a key role in regulating intestinal perfusion during neonatal intestinal injury. Findings provide mechanistic insight into NEC pathophysiology and potential therapeutic targets.