Clinical Management in Mixed Gonadal Dysgenesis with Chromosomal Mosaicism: Considerations in Newborns and Adolescents

This article proposes a patient-centered management protocol for mixed gonadal dysgenesis that balances gonadal malignancy risk against preserving endogenous hormones and fertility. The authors advocate for shared decision-making and delayed surgical interventions, addressing both newborn and adolescent care while respecting gender identity development.