Michael Helmrath · Rapid expansion of intestinal secretory lineages following a massive small bowel resection in mice
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Article1 min read·Published Nov 2026

Rapid expansion of intestinal secretory lineages following a massive small bowel resection in mice

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Article · Nov 2026 · 1 min read

In brief

In brief

This study investigates the cellular mechanisms driving intestinal adaptation after massive small bowel resection in a mouse model. Findings reveal rapid expansion of secretory cell lineages in the early post-resection period, providing insights into how the remaining intestine compensates for lost absorptive surface area—critical knowledge for managing short bowel syndrome.

Written by the GCMD Library team from the article.

Michael Helmrath

Following massive small bowel resection (SBR) in mice, there are sustained increases in crypt depth and villus height, resulting in enhanced mucosal surface area. The early mechanisms responsible for resetting and sustaining this increase are presently not understood. We hypothesized that expansion …

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