Article1 min read·Published Nov 2019Older

Nutritional Risks in Adolescents After Bariatric Surgery

Part of Short Bowel Syndrome & Intestinal Failure 8 items

pubmed.ncbi.nlm.nih.gov

Michael Helmrath

Background & Aims: Little is known about prevalence and risk factors for nutritional deficiencies in adolescents after metabolic bariatric surgery. We performed a 5-year prospective cohort study of these. Methods: Adolescents who had Roux-en-Y gastric bypass (RYGB, n = 161) or vertical sleeve gastrectomy (VSG, n = 67) were enrolled at 5 tertiary-care centers from March 2007 through February 2012. The final analysis cohort included 226 participants (161 who had RYGB and 65 who had VSG). We measured serum levels of ferritin; red blood cell folate; vitamins A, D, B1, B12; and parathyroid hormone at baseline and annually for 5 years. General linear mixed models were used to examine changes over time and identify factors associated with nutritional deficiencies. Results: The participants were 75% female and 72% white, with a mean age of 16.5 ± 1.6 years and mean body mass index of 52.7 ± 9.4 kg/m2 at surgery. Mean body mass index decreased 23% at 5 years, and did not differ significantly between procedures. After RYGB, but not VSG, serum concentrations of vitamin B12 significantly decreased whereas serum levels of transferrin and parathyroid hormone increased. Ferritin levels decreased significantly after both procedures. Hypo-ferritinemia was observed in 2.5% of patients before RYGB and 71% at 5 y after RYGB (P < .0001), and 11% of patients before VSG and 45% 5 y after VSG (P = .002). No significant changes in serum levels of folate or vitamins A, B1, or D were found between base

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Article · Nov 2019 · 1 min read

In brief

This 5-year prospective study of 226 adolescents demonstrates significant nutritional risks following bariatric surgery, particularly iron deficiency which increased from 2.5% to 71% after RYGB and 11% to 45% after VSG. The research identifies procedure-specific deficiency patterns and emphasizes the critical need for long-term micronutrient monitoring in adolescent bariatric patients.

Written by the GCMD Library team from the article.

Michael Helmrath

Statements in this article

The study enrolled 161 adolescents who had Roux-en-Y gastric bypass and 67 who had vertical sleeve gastrectomy at five tertiary-care centers from March 2007 through February 2012.
ResearchMethods
Serum levels of ferritin, red blood cell folate, vitamins A, D, B1, B12, and parathyroid hormone were measured at baseline and annually for five years.
ResearchMethods
The participants were 75% female and 72% white, with a mean age of 16.5 ± 1.6 years and mean body mass index of 52.7 ± 9.4 kg/m² at surgery.
ResearchResults
Mean body mass index decreased 23% at five years and did not differ significantly between procedures.
ResearchResults
After Roux-en-Y gastric bypass, but not vertical sleeve gastrectomy, serum concentrations of vitamin B12 significantly decreased.
ResearchResults
After Roux-en-Y gastric bypass, but not vertical sleeve gastrectomy, serum levels of transferrin and parathyroid hormone increased.
ResearchResults
Ferritin levels decreased significantly after both Roux-en-Y gastric bypass and vertical sleeve gastrectomy.
ResearchResults
Hypoferritinemia was observed in 2.5% of patients before Roux-en-Y gastric bypass and 71% at five years after Roux-en-Y gastric bypass.
ResearchResults
Hypoferritinemia was observed in 11% of patients before vertical sleeve gastrectomy and 45% five years after vertical sleeve gastrectomy.
ResearchResults
No significant changes in serum levels of folate or vitamins A, B1, or D were found between baseline and five years after either procedure.
ResearchResults