Epithelial PIK3R1 (p85) and TP53 Regulate Survivin Expression during Adaptation to Ileocecal Resection.
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Read the article on pubmed.ncbi.nlm.nih.gov ↗Article · Nov 2026 · 1 min read
In brief
In brief
This study investigates how PIK3R1 and TP53 regulate survivin expression in intestinal epithelial cells following ileocecal resection, a critical process for intestinal adaptation after necrotizing enterocolitis. Understanding these molecular mechanisms may inform therapeutic strategies to enhance enteral autonomy in short bowel syndrome patients.
Written by the GCMD Library team from the article.
Statements in this article
Intestinal adaptation to small-bowel resection after necrotizing enterocolitis expands absorptive surface areas and promotes enteral autonomy.
Survivin increases proliferation and blunts apoptosis in intestinal epithelial cells.
Wild-type and epithelial Pik3r1 (p85α)-deficient mice underwent 30% ileocecal resection in this study.