From
Dr. Michael Helmrath
Toll-like Receptor 9 Pathway Mediates Schlafen+-MDSC Polarization During Helicobacter-induced Gastric Metaplasias
pubmed.ncbi.nlm.nih.gov shows its articles on its own site.
Read the article on pubmed.ncbi.nlm.nih.gov ↗Article · Nov 2026 · 1 min read
In brief
In brief
This study identifies TLR9 as a critical mediator of immune cell polarization during Helicobacter infection, driving interferon-alpha production and Schlafen-positive MDSC development in gastric metaplasia. Patients with the rs5743836 TLR9 variant face increased risk of neoplastic progression during chronic infection.
Written by the GCMD Library team from the article.
TLR9 plays an essential role in the production of IFNα and polarization of SLFN+ MDSCs on Helicobacter infection. Subjects carrying the rs5743836 TLR9 minor C allele are predisposed to neoplastic complications if chronically infected.
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