Efficacy and safety of stereotactic radiosurgery versus whole brain radiotherapy for the treatment of brain metastasis: a systematic review and meta-analysis

This meta-analysis comparing stereotactic radiosurgery (SRS) to whole brain radiotherapy for brain metastases found that SRS improves survival and local control while better preserving cognitive function and quality of life, though with higher distant brain recurrence rates. SRS is recommended as preferred treatment for high-risk patients based on its superior safety profile.