Omega-3 fatty acids are protective in hepatic ischemia reperfusion injury in the absence of GPR120 signaling

This experimental study demonstrates that intravenous fish oil administration protects against hepatic ischemia reperfusion injury in mice, reducing liver necrosis by 26-37% regardless of GPR120 receptor presence. The findings suggest omega-3 fatty acids confer hepatoprotection through GPR120-independent mechanisms, with implications for liver transplantation and hepatic surgery protocols.