Inhibiting hydrogen sulfide production in umbilical stem cells reduces their protective effects during experimental necrotizing enterocolitis

Experimental study demonstrates that umbilical mesenchymal stem cells reduce necrotizing enterocolitis severity in neonatal mice through hydrogen sulfide production. When H2S synthesis was inhibited via siRNA, the protective effects were significantly diminished, confirming the critical role of paracrine H2S signaling in stem cell-mediated intestinal protection.