Dithizone-induced Paneth cell disruption significantly decreases intestinal perfusion in the murine small intestine

Experimental study in immature mice demonstrates that chemical disruption of Paneth cells with dithizone significantly reduces intestinal microvascular perfusion, associated with decreased nitric oxide synthase expression. Findings support the role of Paneth cells in regulating intestinal blood flow and provide mechanistic insight into necrotizing enterocolitis pathophysiology.