Plasma Sodium as a predictor of perforation in acute appendicitis: A prospective multi-centre study

Abstract

The traditional perception of acute appendicitis (AA) as an inevitably progressive disease, always ending up in complex disease including perforation has been challenged. Early, emergent surgery is not always warranted in uncomplicated cases and non-operative treatment has been proven safe and feasible1-3. There is emerging consensus on two types of AA: one with mild inflammation, possibly managed with antibiotics or even non-antibiotic, non-operative treatment, and another more severe type with fulminant inflammation and subsequent risk of gangrene and perforation, where surgical removal is first line treatment4.

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