Diagnostic and prognostic utility of SF1, IGF2 and p57 immunoexpression in pediatric adrenal cortical tumors

Study of 25 pediatric adrenocortical tumors demonstrates that SF-1 and IGF2 immunostaining, combined with Ki67 labeling index, provides reliable diagnostic and prognostic assessment when using Weineke criteria. Increased expression of these markers correlates with malignancy and worse survival, while p57 helps identify benign tumors.