Alginate microparticles loaded with basic fibroblast growth factor induce tissue coverage in a rat model of myelomeningocele

This study demonstrates a novel minimally invasive prenatal treatment for myelomeningocele using alginate microparticles loaded with basic fibroblast growth factor. In a rat model, intraamniotic injection of these particles achieved 30% soft tissue coverage of spinal defects, significantly outperforming controls and free growth factor alone.