Ogerin Inhibits Development of Post-Operative Abdominal Adhesions in a Murine Model

Abstract

Adhesions form as a response to peritoneal tissue trauma. Myofibroblast collagen production is key to adhesion formation and ogerin can prevent myofibroblast differentiation in tissue-resident fibroblast populations. In this two-part study, we sought to evaluate ogerin’s potential to prevent myofibroblast differentiation, in vitro, and adhesion formation in vivo.

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