# Pancreatitis in pediatric patients with pancreatic solid pseudopapillary neoplasms- a single center experience — GCMD Library Stephen J Hartman, Nicolas Noriega, Raphael M Parrado, Emily Vore, Andrew Trout, David Vitale, Maisam Abu-El-Haija, Juan P Gurria

Background: Though rare, solid pseudopapillary neoplasms (SPN) are one of the most common, low-grade, malignant pediatric pancreatic neoplasms in children and young adults and are associated with a good prognosis. This study seeks to describe characteristics, genetics and outcomes of patients who underwent SPN resection.

Methods: A single-center retrospective series of pediatric patients who underwent SPN resection from 2010 to 2023. SPN location, surgical intervention, and rates of acute recurrent and chronic pancreatitis (ARP, CP) were summarized. Patients who developed ARP/CP underwent pancreatitis-specific genetic testing.

Results: Ten patients were included, all of whom were female. Median age at diagnosis was 15.0 years (13.8, 18.3). Half (n = 5) underwent preoperative endoscopic ultrasound (EUS). Five patients underwent pancreaticoduodenectomy, the remainder underwent partial pancreatectomy. Of the three patients who went on to develop post-operative ARP/CP all had SPN lesions of the pancreatic head. Individual histories were notable for an established risk alle heterozygous CFTR variant, a heterozygous CFTR variant of unknown significance, and pancreas divisum with pancreaticojejunostomy (PJ) stricture respectively. One patient initially presented with acute pancreatitis with known PRSS1 MLPA duplication, but did not progress to ARP/CP. Three patients required completion pancreatectomy with islet autotransplantation.

Conclusions: These data represent a unique pediatric patient population requiring coordinated, multi-disciplinary care. Given the identification of either hereditary gene mutations or pancreas divisum in all patients who developed ARP/CP after SPN resection, genetic and anatomic evaluation prior to resection might provide greater understanding of post-operative outcomes after resection. Further evaluation is needed among pediatric patients with SPN.
Type: video · 0 min · posted 2026-04-13 Canonical: https://library.globalcastmd.com/watch/pancreatitis-in-pediatric-patients-with-pancreatic-solid-pseudopapillary-neoplasms-a-single-center-experience-11847 ## Chapters - [0:00](https://library.globalcastmd.com/watch/pancreatitis-in-pediatric-patients-with-pancreatic-solid-pseudopapillary-neoplasms-a-single-center-experience-11847?t=0) Post-resection pancreatitis risk in pediatric solid pseudopapillary neoplasms ## Statements - "Solid pseudopapillary neoplasms are one of the most frequent pancreatic tumors in pediatric patients" — Lizzie Lee (epidemiological) [0:09](https://library.globalcastmd.com/watch/pancreatitis-in-pediatric-patients-with-pancreatic-solid-pseudopapillary-neoplasms-a-single-center-experience-11847?t=9) - "Surgery for solid pseudopapillary neoplasms is usually curative and outcomes are excellent" — Lizzie Lee (clinical) [0:15](https://library.globalcastmd.com/watch/pancreatitis-in-pediatric-patients-with-pancreatic-solid-pseudopapillary-neoplasms-a-single-center-experience-11847?t=15) - "In a single center study, 10 adolescent girls underwent surgical resection for solid pseudopapillary neoplasms" — Lizzie Lee (clinical) [0:22](https://library.globalcastmd.com/watch/pancreatitis-in-pediatric-patients-with-pancreatic-solid-pseudopapillary-neoplasms-a-single-center-experience-11847?t=22) - "3 out of 10 patients developed acute recurrent or chronic pancreatitis after resection" — Lizzie Lee (clinical) [0:25](https://library.globalcastmd.com/watch/pancreatitis-in-pediatric-patients-with-pancreatic-solid-pseudopapillary-neoplasms-a-single-center-experience-11847?t=25) - "Every patient who developed ongoing pancreatitis had genetic risk factors like CFTR gene variants or pancreas divisum" — Lizzie Lee (clinical) [0:32](https://library.globalcastmd.com/watch/pancreatitis-in-pediatric-patients-with-pancreatic-solid-pseudopapillary-neoplasms-a-single-center-experience-11847?t=32) - "Some patients with post-resection pancreatitis ultimately required completion pancreatectomy" — Lizzie Lee (clinical) [0:40](https://library.globalcastmd.com/watch/pancreatitis-in-pediatric-patients-with-pancreatic-solid-pseudopapillary-neoplasms-a-single-center-experience-11847?t=40) - "Identifying genetic and anatomic risk factors before surgery may change management of patients with solid pseudopapillary neoplasms" — Lizzie Lee (opinion) [0:48](https://library.globalcastmd.com/watch/pancreatitis-in-pediatric-patients-with-pancreatic-solid-pseudopapillary-neoplasms-a-single-center-experience-11847?t=48) ## Transcript What if curing a rare pancreatic tumor sets the stage for chronic pancreatitis? I'm Lizzie Lee from Cincinnati Children's, and this is an article you should know about. Solid pseudopapillary neoplasms are uncommon, but in pediatric patients, they're one of the most frequent pancreatic tumors. Surgery is usually curative and outcomes are excellent, but this single center study tells a deeper story. 10 adolescent girls underwent surgical resection. Most recovered well, but 3 went on to develop acute recurrent or chronic pancreatitis. Here's the striking part. Every patient who developed ongoing pancreatitis had genetic risk factors like the CFTR gene variant, or they had pancreas divisum. Some ultimately required completion pancreatectomy. What's the takeaway? Even low grade tumors can carry high stakes consequences. Identifying genetic and anatomic risk factors before doing surgery may change how we manage these patients. Let us know what you think in the comments below and stay tuned for more articles that you should know about. --- Not medical advice · citation policy: https://library.globalcastmd.com/ai