New article you should know by Cecilia Gigena
"Disruption of enterohepatic Circulation of Bile acids ameliorates small bowel resection associated hepatic injury"
Authors: Maria E. Tecos, Allie E. Steinberger, Jun Guo, Deborah C. Rubin, Nicholas O. Davidson, Brad W. Warner
Full article: https://www.jpedsurg.org/article/S0022-3468(23)00152-5/fulltext
Background
Massive small bowel resection (SBR) is associated with liver injury and fibrosis. Efforts to elucidate the driving force behind hepatic injury have identified multiple factors, including the generation of toxic bile acid metabolites.
Methods
Sham, 50% proximal, and 50% distal SBR were carried out in C57BL/6 mice to determine the effect of jejunal (proximal SBR) versus ileocecal resection (distal SBR) on bile acid metabolism and liver injury. Tissues were harvested at 2 and 10-week postoperative timepoints.
Results
When compared with 50% proximal SBR, mice that underwent distal SBR exhibited less hepatic oxidative stress as verified by decreased mRNA expression of tumor necrosis factor-α (TNFα, p ≤ 0.0001), nicotinamide adenine dinucleotide phosphate oxidase (NOX, p ≤ 0.0001), and glutathione synthetase (GSS, p ≤ 0.05). Distal SBR mice also exhibited a more hydrophilic bile acid profile with reduced abundance of insoluble bile acids (cholic acid (CA), taurodeoxycholic acid (TCA), and taurolithocholic acid (TLCA)), and increased abundance of soluble bile acids (tauroursodeoxycholic acid (TUDCA)). In contrast with proximal SBR, ileocecal resection alters enterohepatic circulation leading to reduced oxidative stress and promotes physiological bile acid metabolism.
Conclusion
These findings challenge the notion that preservation of the ileocecal region is beneficial in patients with short bowel syndrome. Administration of selected bile acids may present potential therapy to mitigate resection-associated liver injury.
Type: video · 0 min · posted 2023-08-23 Canonical: https://library.globalcastmd.com/watch/disruption-of-enterohepatic-circulation-of-bile-acids-ameliorates-small-bowel-resection-associated-hepatic-injury-7050 ## Chapters - [0:00](https://library.globalcastmd.com/watch/disruption-of-enterohepatic-circulation-of-bile-acids-ameliorates-small-bowel-resection-associated-hepatic-injury-7050?t=0) Enterohepatic Circulation Disruption and Hepatic Injury in Small Bowel Resection ## Statements - "Disruption of the enterohepatic circulation of bile acids is beneficial for the liver" — Cecilia Gigena (clinical) [0:00](https://library.globalcastmd.com/watch/disruption-of-enterohepatic-circulation-of-bile-acids-ameliorates-small-bowel-resection-associated-hepatic-injury-7050?t=0) - "The study was conducted at Saint Louis Children's Hospital" — Cecilia Gigena (clinical) [0:13](https://library.globalcastmd.com/watch/disruption-of-enterohepatic-circulation-of-bile-acids-ameliorates-small-bowel-resection-associated-hepatic-injury-7050?t=13) - "The study aim was to elucidate the driving force behind hepatic injury" — Cecilia Gigena (clinical) [0:13](https://library.globalcastmd.com/watch/disruption-of-enterohepatic-circulation-of-bile-acids-ameliorates-small-bowel-resection-associated-hepatic-injury-7050?t=13) - "Three groups of mice were studied: sham, 50% with proximal or duodenal resection, and 50% with distal resection or resection of the ileocecal valve" — Cecilia Gigena (clinical) [0:22](https://library.globalcastmd.com/watch/disruption-of-enterohepatic-circulation-of-bile-acids-ameliorates-small-bowel-resection-associated-hepatic-injury-7050?t=22) - "Tissue samples were taken at the second and 10th postoperative weeks" — Cecilia Gigena (clinical) [0:34](https://library.globalcastmd.com/watch/disruption-of-enterohepatic-circulation-of-bile-acids-ameliorates-small-bowel-resection-associated-hepatic-injury-7050?t=34) - "Mice with distal resection show less hepatic oxidative stress" — Cecilia Gigena (clinical) [0:41](https://library.globalcastmd.com/watch/disruption-of-enterohepatic-circulation-of-bile-acids-ameliorates-small-bowel-resection-associated-hepatic-injury-7050?t=41) - "Mice with distal resection show more hydrophilic bile acid profile" — Cecilia Gigena (clinical) [0:41](https://library.globalcastmd.com/watch/disruption-of-enterohepatic-circulation-of-bile-acids-ameliorates-small-bowel-resection-associated-hepatic-injury-7050?t=41) - "Ileal resection could lead to less hepatic injury" — Cecilia Gigena (clinical) [0:41](https://library.globalcastmd.com/watch/disruption-of-enterohepatic-circulation-of-bile-acids-ameliorates-small-bowel-resection-associated-hepatic-injury-7050?t=41) ## Transcript Did you know that the disruption of the enterohepatic circulation of bilasses is beneficial for the liver? Hi, I'm Cecilia Jigena from Cincinnati Children's Hospital, and this is an article that you should know about. This is a basic science study done in Saint Louis Children's Hospital, and their aim was to elucidate the driving force behind the hepatic injury. For that they have three groups of mice sham, 50% with proximal or duojunal resection, and 50% with distal resection or the resection of the ileocecal valve. And then they took tissue samples and the second and 10th. Post-op weeks and what did they find? They find that mice with distal resection show less hepatic oxidative stress and more hydrophilic bile acid profile, meaning that the ilisal resection could lead to less hepatic injury. Let us know what you think and stay tuned for more articles that you should know about. --- Not medical advice · citation policy: https://library.globalcastmd.com/ai