Current management of pulmonary relapse in Ewing sarcoma: A report from the Pediatric Surgical Oncology Research Collaborative

Writer et al. published a multi-center retrospective study in the Journal of Pediatric Surgery through PeaceSOC in 2024

PeaceSOC is a network of over 50 centers in North America that work together to improve outcomes in pediatric surgical oncology

The study examined patients less than 22 years old with initially localized Ewing sarcoma who developed first pulmonary relapse between 2007 and 2020 across 19 different centers

Among 33 patients studied, about 2/3 had relapse limited to the lungs

Nearly half of patients with lung-limited relapse had just a solitary pulmonary nodule

Patients with solitary pulmonary nodule were more likely to undergo metastasectomy and whole lung radiation

Patients with solitary pulmonary nodule had the highest overall three-year survival at 73%

Three-year survival for patients with multiple nodules was 40%

Three-year survival for patients with extrapulmonary disease was 23%

Solitary pulmonary relapse may represent a biologically more favorable type of recurrence

Solitary pulmonary relapse is more amenable to achieving meaningful local control

Metastasectomy plays an important role as part of multimodal therapy for solitary pulmonary relapse in Ewing sarcoma