New Article you should know by Dr. Cecilia Gigena from Journal of Pediatric Surgery.
"Clinical Characteristics and Prognosis of Biliary Atresia with Low Serum Matrix Metalloproteinase-7 Levels"
Authors: Jingying Jiang, Yifan Yang, Xue Ren, Chen Xu, Chunjing Ye, Jin Zhou, Manning Qian, Shuxin Wang, Gong Chen, Rui Dong, Shan Zheng
Full article: https://gcmd.co/3zOQlqx
Purpose
Serum matrix metalloproteinase-7 (MMP-7) levels can precisely differentiate biliary atresia (BA) from non-BA cholestasis. However, serum MMP-7 levels of some BA patients were within normal range or slightly elevated. This study aimed to investigate the clinical characteristics and prognosis of biliary atresia with low serum MMP-7 levels.
Method
This is a retrospective cohort study. Cases of BA from July 2020 to December 2022 were consecutively enrolled. They were divided into low-MMP-7 group (MMP-7 ≤ 25 ng/ml) and high-MMP-7 group (MMP-7 > 25 ng/ml) according to serum MMP-7 levels preoperatively. The perioperative clinical characteristics, the 3-month and 6-month jaundice clearance rate post-Kasai procedure, and the native liver survival were compared between the two groups.
Results
A total of 329 cases were included in this study, 40 of which were divided into the low-MMP-7 group. Preoperative GGT and direct bilirubin levels in the low-MMP-7 group were significantly lower than those in the high-MMP-7 group (258.6 U/L, interquartile range [IQR]: 160.4411.6 vs. 406.8 IU/L, IQR: 215,655.0, P = 0.0076; 103.8 μmol/L, IQR: 79.0,121.4 vs. 115.3 μmol/L, IQR: 94,138.8, P = 0.0071), while the gender, the day at surgery and preoperative ALT, AST, TBA, total bilirubin levels showed no significant differences (P > 0.05). The 3-month and 6-month jaundice clearance rate post-Kasai procedure in the low-MMP-7 group were lower than those in the high-MMP-7 group (29.73% vs. 53.09%, P = 0.049; 32.14% vs. 54.73%, P = 0.023). The 1-year native liver survival rate was 29.63% for the low-MMP-7 group and 53.02% for the high-MMP-7 group (P = 0.022).
Conclusion
Preoperative clinical characteristics were similar between low-MMP-7 group and high-MMP-7 group, while patients with low serum MMP-7 levels showed worse prognosis, indicating that this might be listed as a new clinical subtype of BA which could contribute to designing new treatment strategies for BA in the future.
Type: video · 0 min · posted 2024-07-23 Canonical: https://library.globalcastmd.com/watch/clinical-characteristics-and-prognosis-of-biliary-atresia-with-low-serum-matrix-metalloproteinase-7-levels-8911 ## Chapters - [0:00](https://library.globalcastmd.com/watch/clinical-characteristics-and-prognosis-of-biliary-atresia-with-low-serum-matrix-metalloproteinase-7-levels-8911?t=0) MMP-7 as a Prognostic Marker in Biliary Atresia ## Statements - "The study was a retrospective cohort study conducted in China" — Cecilia Gigena (epidemiological) [0:11](https://library.globalcastmd.com/watch/clinical-characteristics-and-prognosis-of-biliary-atresia-with-low-serum-matrix-metalloproteinase-7-levels-8911?t=11) - "The study included 329 patients with biliary atresia" — Cecilia Gigena (epidemiological) [0:21](https://library.globalcastmd.com/watch/clinical-characteristics-and-prognosis-of-biliary-atresia-with-low-serum-matrix-metalloproteinase-7-levels-8911?t=21) - "40 of the 329 patients had low MMP-7 levels" — Cecilia Gigena (epidemiological) [0:21](https://library.globalcastmd.com/watch/clinical-characteristics-and-prognosis-of-biliary-atresia-with-low-serum-matrix-metalloproteinase-7-levels-8911?t=21) - "Patients with low MMP-7 had significantly lower 3-month jaundice clearance" — Cecilia Gigena (clinical) [0:27](https://library.globalcastmd.com/watch/clinical-characteristics-and-prognosis-of-biliary-atresia-with-low-serum-matrix-metalloproteinase-7-levels-8911?t=27) - "Patients with low MMP-7 had significantly lower 6-month jaundice clearance" — Cecilia Gigena (clinical) [0:27](https://library.globalcastmd.com/watch/clinical-characteristics-and-prognosis-of-biliary-atresia-with-low-serum-matrix-metalloproteinase-7-levels-8911?t=27) - "Patients with low MMP-7 had significantly lower 1-year native liver survival" — Cecilia Gigena (clinical) [0:27](https://library.globalcastmd.com/watch/clinical-characteristics-and-prognosis-of-biliary-atresia-with-low-serum-matrix-metalloproteinase-7-levels-8911?t=27) - "Measuring MMP-7 can help with prognosis in biliary atresia patients" — Cecilia Gigena (opinion) [0:40](https://library.globalcastmd.com/watch/clinical-characteristics-and-prognosis-of-biliary-atresia-with-low-serum-matrix-metalloproteinase-7-levels-8911?t=40) - "MMP-7 measurement may in the future help with treatment of biliary atresia patients" — Cecilia Gigena (opinion) [0:40](https://library.globalcastmd.com/watch/clinical-characteristics-and-prognosis-of-biliary-atresia-with-low-serum-matrix-metalloproteinase-7-levels-8911?t=40) ## Transcript Do you take matrix metaloproteina7 in patients with biliary atresia? Hi, I'm Cecilia Jigenna from Cincinnati Children's Hospital, and I think this is an article that you should know about. This is a retrospective cohort study done in China that aimed to evaluate the characteristics and prognosis of patients with biliary atresia and low MMP 7. They had 329 patients, and 40 of them had low MMP7. And what they found is that these patients had significantly lower 3 month and 6 month jaundice clearance and significantly lower 1 year native liver survival. So it seems that measuring MMP 7 can help with the prognosis and in the future maybe even with treatment of patients with biliary atresia. Let us know what you think and stay tuned for more articles that you should know about. --- Not medical advice · citation policy: https://library.globalcastmd.com/ai