# BOB Ped Surg 2023 - Steven Scoville, IPSO - Presentation — GCMD Library

Watch Steven Scoville MD, present his presentation on "Comparison of outcomes between surveillance ultrasound and completion lymph node dissection in children and adolescents with sentinel lymph node positive cutaneous melanoma."

Type: video · 5 min · posted 2023-02-06 Canonical: https://library.globalcastmd.com/watch/bob-ped-surg-2023-steven-scoville-ipso-presentation-6343 ## Chapters - [0:11](https://library.globalcastmd.com/watch/bob-ped-surg-2023-steven-scoville-ipso-presentation-6343?t=11) Introduction and Background - [1:54](https://library.globalcastmd.com/watch/bob-ped-surg-2023-steven-scoville-ipso-presentation-6343?t=114) Study Design and Patient Cohort - [3:22](https://library.globalcastmd.com/watch/bob-ped-surg-2023-steven-scoville-ipso-presentation-6343?t=202) Results and Outcomes Analysis - [4:23](https://library.globalcastmd.com/watch/bob-ped-surg-2023-steven-scoville-ipso-presentation-6343?t=263) Conclusions and Acknowledgments ## Statements - "Pediatric melanoma has approximately 500 new cases diagnosed annually in children less than or equal to 18 years old" — Steven Scoville (epidemiological) [0:26](https://library.globalcastmd.com/watch/bob-ped-surg-2023-steven-scoville-ipso-presentation-6343?t=26) - "Childhood melanoma is associated with delayed diagnosis and more frequently has nodal involvement compared to adults" — Steven Scoville (clinical) [0:33](https://library.globalcastmd.com/watch/bob-ped-surg-2023-steven-scoville-ipso-presentation-6343?t=33) - "Childhood melanoma has unique disease mechanisms compared to adult melanoma" — Steven Scoville (clinical) [0:42](https://library.globalcastmd.com/watch/bob-ped-surg-2023-steven-scoville-ipso-presentation-6343?t=42) - "Management of pediatric melanoma is based on adult studies" — Steven Scoville (guideline) [0:44](https://library.globalcastmd.com/watch/bob-ped-surg-2023-steven-scoville-ipso-presentation-6343?t=44) - "Melanoma management is largely based on depth of the tumor and presence of metastatic disease" — Steven Scoville (guideline) [0:49](https://library.globalcastmd.com/watch/bob-ped-surg-2023-steven-scoville-ipso-presentation-6343?t=49) - "Tumors less than 8 millimeters thick are largely managed with wide local excision" — Steven Scoville (guideline) [0:55](https://library.globalcastmd.com/watch/bob-ped-surg-2023-steven-scoville-ipso-presentation-6343?t=55) - "Tumors greater than or equal to 8 millimeters or less than 8 millimeters with high risk features without metastatic involvement typically undergo wide local excision with sentinel lymph node biopsies" — Steven Scoville (guideline) [1:07](https://library.globalcastmd.com/watch/bob-ped-surg-2023-steven-scoville-ipso-presentation-6343?t=67) - "Completion lymph node dissection has a high risk of morbidity" — Steven Scoville (clinical) [1:20](https://library.globalcastmd.com/watch/bob-ped-surg-2023-steven-scoville-ipso-presentation-6343?t=80) - "Two adult trials (DCOG SLT and MSLT2) showed no significant difference in outcomes for low to intermediate risk patients with positive sentinel lymph node biopsies who were followed with ultrasound observation versus completion lymph node dissections" — Steven Scoville (guideline) [1:29](https://library.globalcastmd.com/watch/bob-ped-surg-2023-steven-scoville-ipso-presentation-6343?t=89) - "There is no pediatric data to support ultrasound observation versus completion lymph node dissection" — Steven Scoville (epidemiological) [1:47](https://library.globalcastmd.com/watch/bob-ped-surg-2023-steven-scoville-ipso-presentation-6343?t=107) - "The study included 252 patients less than or equal to 18 years old diagnosed with cutaneous melanoma between 2010 and 2020 from 14 institutions through PSORC" — Steven Scoville (epidemiological) [1:54](https://library.globalcastmd.com/watch/bob-ped-surg-2023-steven-scoville-ipso-presentation-6343?t=114) - "Race was predominantly white in the study cohort, consistent with prior literature" — Steven Scoville (epidemiological) [2:10](https://library.globalcastmd.com/watch/bob-ped-surg-2023-steven-scoville-ipso-presentation-6343?t=130) - "Breslow depth ranged from tumor in situ to 20 millimeters with a median of 2.55 millimeters" — Steven Scoville (epidemiological) [2:21](https://library.globalcastmd.com/watch/bob-ped-surg-2023-steven-scoville-ipso-presentation-6343?t=141) - "Extent of disease was nearly split between localized and regionalized disease" — Steven Scoville (epidemiological) [2:21](https://library.globalcastmd.com/watch/bob-ped-surg-2023-steven-scoville-ipso-presentation-6343?t=141) - "Of 227 patients who underwent wide local excision with sentinel lymph node biopsies, 115 had positive sentinel lymph nodes (approximately 51%)" — Steven Scoville (epidemiological) [2:40](https://library.globalcastmd.com/watch/bob-ped-surg-2023-steven-scoville-ipso-presentation-6343?t=160) - "Patients who underwent completion lymph node dissection were significantly older than those who underwent ultrasound observation" — Steven Scoville (epidemiological) [3:22](https://library.globalcastmd.com/watch/bob-ped-surg-2023-steven-scoville-ipso-presentation-6343?t=202) - "Patients who underwent completion lymph node dissection were more likely to receive adjuvant therapy" — Steven Scoville (epidemiological) [3:22](https://library.globalcastmd.com/watch/bob-ped-surg-2023-steven-scoville-ipso-presentation-6343?t=202) - "There was no significant difference in recurrence or death from disease between ultrasound observation and completion lymph node dissection groups" — Steven Scoville (clinical) [3:34](https://library.globalcastmd.com/watch/bob-ped-surg-2023-steven-scoville-ipso-presentation-6343?t=214) - "Positive sentinel lymph node biopsies had significantly higher rate of disease recurrence at 18% compared to 3% for negative sentinel lymph node biopsy group" — Steven Scoville (clinical) [3:41](https://library.globalcastmd.com/watch/bob-ped-surg-2023-steven-scoville-ipso-presentation-6343?t=221) - "Only 21% of those who underwent completion lymph node dissection had additional positive nodal disease" — Steven Scoville (clinical) [3:52](https://library.globalcastmd.com/watch/bob-ped-surg-2023-steven-scoville-ipso-presentation-6343?t=232) - "Rate of recurrence was not significantly different between completion lymph node dissection patients with or without additional nodal burden" — Steven Scoville (clinical) [4:01](https://library.globalcastmd.com/watch/bob-ped-surg-2023-steven-scoville-ipso-presentation-6343?t=241) - "Recurrence was associated with positive nodal disease, deeper Breslow depth, greater use of adjuvant therapy, and higher rate of death" — Steven Scoville (clinical) [4:11](https://library.globalcastmd.com/watch/bob-ped-surg-2023-steven-scoville-ipso-presentation-6343?t=251) - "Pediatric melanoma presents as advanced disease with nearly 50% positive sentinel lymph node biopsy rate" — Steven Scoville (epidemiological) [4:23](https://library.globalcastmd.com/watch/bob-ped-surg-2023-steven-scoville-ipso-presentation-6343?t=263) - "Management of nodal disease had no significant impact on disease outcomes with respect to recurrence or death from disease" — Steven Scoville (clinical) [4:30](https://library.globalcastmd.com/watch/bob-ped-surg-2023-steven-scoville-ipso-presentation-6343?t=270) - "Findings of additional nodal disease in completion lymph node dissection did not significantly correlate with recurrence" — Steven Scoville (clinical) [4:38](https://library.globalcastmd.com/watch/bob-ped-surg-2023-steven-scoville-ipso-presentation-6343?t=278) - "Recurrence most strongly associated with positive sentinel lymph node biopsies and deeper Breslow depth" — Steven Scoville (clinical) [4:47](https://library.globalcastmd.com/watch/bob-ped-surg-2023-steven-scoville-ipso-presentation-6343?t=287) ## Transcript I'd like to thank you for this opportunity to present our work entitled Comparison of Outcomes Between Surveillance ultrasound and Completion Lymph node dissection in children and adolescents with sentinel lymph node positive cutaneous melanoma. We have no disclosure. Pediatric melanoma has approximately 500 new cases diagnosed annually in children less than or equal to 18 years old. Compared to adults, we know that childhood melanoma is associated with delayed diagnosis and therefore, not surprisingly, more frequently has nodal involvement. It also has unique disease mechanisms. Despite these differences though, management of pediatric melanoma is based on adult studies. Melanoma management is largely based on depth of the tumor, as well as presence of metastatic disease. Those with disease less than 8 millimeters thick are largely managed with wide local excision, while those with metastatic disease typically involve consideration of surgical excision and or systemic therapy. Those in the middle category of having tumors greater than or equal to 8 millimeters or less than 8 millimeters with high risk features without the presence of metastatic involvement, typically undergo wide local excision with sentinel lymph node biopsies. If the sentinel lymph node biopsy is positive, then these patients would typically undergo ultrasound observation versus a completion lymph node dissection, which has a high risk of morbidity. Within the past 6 years, two adult trials known as the DCOG SLT and the MSLT2 trials helped to show that within these low to intermediate risk patients, there's no significant difference in outcomes for patients with positive sentinel lymph node biopsies who were followed with ultrasound observation versus completion lymph node dissections. However, there is no pediatric data to support one versus the other. Therefore, we set out to answer this question. Our study included patients less than or equal to 18 years old, diagnosed with cutaneous melanoma between 2010 and 2020. 14 total institutions participated through the Pediatric surgical Oncology Research Collaborative, otherwise known as PSO. Of the 252 patients included in this study, we found nearly equal distribution of age, tumor location, while race was predominantly white, consistent with prior literature. Breslow depth ranged from tumor in situ to 20 millimeters in depth, with a median of 2.55 millimeters and extent of disease was nearly split between localized and regionalized disease. In categorizing our patients, we had 4 patients who underwent wide local excision alone that went on to undergo ultrasound observation. We then had a total of 227 patients who underwent wide local excision with sentinel lymph node biopsies. 111 of these had negative sentinel lymph nodes, with 6 of those who went on to undergo ultrasound observation. In contrast, 115 patients had positive sentinel lymph node biopsies, about 51%. Of those, 36 went on to have ultrasound observations, whereas 65 underwent completion lymph node dissections. Finally, 2 patients had wide local excision alone or had unknown sentinel lymph node biopsy results, went on to have completion lymph node dissections. For a total of 46 patients in the ultrasound observation group compared to 67 that had completion lymph node dissections. Comparing outcomes between ultrasound observation versus completion lymph node dissection, we found that patients who underwent completion lymph node dissection were significantly older and more likely to receive adjuvant therapy. Furthermore, there was no significant differences between recurrence or death from disease between these two groups. Additional subgroup analysis found that positive sentinel lymph node biopsies had significantly higher rate of disease recurrence at 18% compared to 3% for the negative sentinel lymph node biopsy group. We also found that only 21% of those who underwent completion lymph node dissection had additional positive nodal disease. However, we found that rate of recurrence was not significantly different between completion lymph node dissection patients with or without additional nodal burden. In doing an analysis based on recurrence versus no recurrence, we found that recurrence was associated with positive mental disease, deeper resal depth, and greater use of adjuvant therapy, and a higher rate of death. Therefore, to summarize, pediatric melanoma presents as advanced disease with nearly 50% positive sentinel lymph node biopsy rate. Management of nodal disease had no significant impact on disease outcomes with respect to recurrence or death from disease. Only 21% of patients that underwent completion lymph node dissection had additional nodes discovered and findings of additional nodal disease did not significantly correlate with recurrence. Recurrence did most strongly associate with positive sentinel lymph node biopsies and deeper Breslow depth. I would like to personally thank our many collaborators across the 14 institutions who helped with our data acquisition, analysis and our manuscript preparation. Thank you. --- Not medical advice · citation policy: https://library.globalcastmd.com/ai