# BOB Ped Surg 2023 - Maria Soledad Jara Valdivia, CIPESUR  - Presentation — GCMD Library

<p>Watch Maria Soledad Jara Valdivia, MD, present her presentation on "The immunohistochemical staining CD56 is useful in the diagnosis of biliary atresia."</p>


Type: video · posted 2023-02-06
Canonical: https://library.globalcastmd.com/watch/bob-ped-surg-2023-maria-soledad-jara-valdivia-cipesur-presentation-6353

## Chapters
- [0:00](https://library.globalcastmd.com/watch/bob-ped-surg-2023-maria-soledad-jara-valdivia-cipesur-presentation-6353?t=0) Introduction and Background
- [1:00](https://library.globalcastmd.com/watch/bob-ped-surg-2023-maria-soledad-jara-valdivia-cipesur-presentation-6353?t=60) Methodology
- [3:00](https://library.globalcastmd.com/watch/bob-ped-surg-2023-maria-soledad-jara-valdivia-cipesur-presentation-6353?t=180) Results
- [4:00](https://library.globalcastmd.com/watch/bob-ped-surg-2023-maria-soledad-jara-valdivia-cipesur-presentation-6353?t=240) Discussion and Conclusions

## Statements
- "Biliary atresia leads to liver cirrhosis without early treatment" — Maria Soledad Jara Valdivia (clinical) [0:00](https://library.globalcastmd.com/watch/bob-ped-surg-2023-maria-soledad-jara-valdivia-cipesur-presentation-6353?t=0)
- "The diagnosis of BA can be challenging as its histopathologic features overlap with those of other pediatric cholestatic liver diseases" — Maria Soledad Jara Valdivia (clinical) [0:20](https://library.globalcastmd.com/watch/bob-ped-surg-2023-maria-soledad-jara-valdivia-cipesur-presentation-6353?t=20)
- "The most helpful hallmark of BA on histology is portal fibrosis and bile duct proliferation" — Maria Soledad Jara Valdivia (clinical) [0:40](https://library.globalcastmd.com/watch/bob-ped-surg-2023-maria-soledad-jara-valdivia-cipesur-presentation-6353?t=40)
- "A similar pattern to BA can be found in other causes of cholestasis such as familiar intrahepatic cholestasis, neonatal hepatitis, and Alagille syndrome" — Maria Soledad Jara Valdivia (clinical) [0:50](https://library.globalcastmd.com/watch/bob-ped-surg-2023-maria-soledad-jara-valdivia-cipesur-presentation-6353?t=50)
- "During cirrhosis, biliary epithelial structure express immunohistochemical markers of immaturity such as CD56" — Maria Soledad Jara Valdivia (clinical) [1:10](https://library.globalcastmd.com/watch/bob-ped-surg-2023-maria-soledad-jara-valdivia-cipesur-presentation-6353?t=70)
- "639 biopsies were performed between 2013 and 2019" — Maria Soledad Jara Valdivia (epidemiological) [3:00](https://library.globalcastmd.com/watch/bob-ped-surg-2023-maria-soledad-jara-valdivia-cipesur-presentation-6353?t=180)
- "Final groups were distributed as: group BA equals 30 patients, group NC equals 28 patients, group C no BA equals 31" — Maria Soledad Jara Valdivia (epidemiological) [3:05](https://library.globalcastmd.com/watch/bob-ped-surg-2023-maria-soledad-jara-valdivia-cipesur-presentation-6353?t=185)
- "CD56 plus had sensitivity of 74% for BA versus 16% and 9% for other groups" — Maria Soledad Jara Valdivia (clinical) [3:20](https://library.globalcastmd.com/watch/bob-ped-surg-2023-maria-soledad-jara-valdivia-cipesur-presentation-6353?t=200)
- "CD56 plus had specificity of 87.7% for BA versus 61% and 50% for other groups" — Maria Soledad Jara Valdivia (clinical) [3:35](https://library.globalcastmd.com/watch/bob-ped-surg-2023-maria-soledad-jara-valdivia-cipesur-presentation-6353?t=215)
- "The PPV was 76% for BA versus 18% and 9% for other groups" — Maria Soledad Jara Valdivia (clinical) [3:45](https://library.globalcastmd.com/watch/bob-ped-surg-2023-maria-soledad-jara-valdivia-cipesur-presentation-6353?t=225)
- "The NPV was 80% for BA versus 57% and 50% for other groups" — Maria Soledad Jara Valdivia (clinical) [3:55](https://library.globalcastmd.com/watch/bob-ped-surg-2023-maria-soledad-jara-valdivia-cipesur-presentation-6353?t=235)
- "The AUC was 0.81" — Maria Soledad Jara Valdivia (clinical) [4:05](https://library.globalcastmd.com/watch/bob-ped-surg-2023-maria-soledad-jara-valdivia-cipesur-presentation-6353?t=245)
- "The labeling quantile from 6 to 25% had a higher sensitivity and adequate specificity" — Maria Soledad Jara Valdivia (clinical) [4:10](https://library.globalcastmd.com/watch/bob-ped-surg-2023-maria-soledad-jara-valdivia-cipesur-presentation-6353?t=250)
- "CD56 in more than 5% of the ductular epithelial cells has a sensitivity of 74.2% versus 16.1% and 9.68% in non-BA groups" — Maria Soledad Jara Valdivia (clinical) [4:30](https://library.globalcastmd.com/watch/bob-ped-surg-2023-maria-soledad-jara-valdivia-cipesur-presentation-6353?t=270)
- "CD56 has specificity of 87.7% and LHR+ of 6.04 compared to 0.42 and 0.20 in non BA group to diagnose biliary atresia" — Maria Soledad Jara Valdivia (clinical) [4:45](https://library.globalcastmd.com/watch/bob-ped-surg-2023-maria-soledad-jara-valdivia-cipesur-presentation-6353?t=285)
- "An NPV of 86.2% shows that if CD56 is negative, biliary atresia is unlikely" — Maria Soledad Jara Valdivia (clinical) [4:55](https://library.globalcastmd.com/watch/bob-ped-surg-2023-maria-soledad-jara-valdivia-cipesur-presentation-6353?t=295)
- "CD56 IHC stain is helpful as a complementary test in liver biopsies to rule out biliary atresia as an etiology for neonates presenting with cholestasis" — Maria Soledad Jara Valdivia (opinion) [5:05](https://library.globalcastmd.com/watch/bob-ped-surg-2023-maria-soledad-jara-valdivia-cipesur-presentation-6353?t=305)

---
Not medical advice · citation policy: https://library.globalcastmd.com/ai