From
Dr. Alexander Bondoc
A developmentally prometastatic niche to hepatoblastoma in neonatal liver mediated by the Cxcl1/Cxcr2 axis
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Read the article on pubmed.ncbi.nlm.nih.gov ↗Article · Oct 2026 · 1 min read
In brief
In brief
This study demonstrates that neonatal liver provides a developmentally distinct prometastatic niche for hepatoblastoma through CXCL1/CXCR2 axis activation. Single-cell RNA sequencing revealed age-dependent differences in tumor microenvironment composition, with neonatal models showing enhanced tumorigenicity and metastatic potential compared to adult liver environments.
Written by the GCMD Library team from the article.
We found that various HB cell lines including HepG2 cells were consistently and considerably more tumorigenic and metastatic in the P5Tx model than in the P60Tx models. Sc-RNAseq of the P5Tx and P60Tx HepG2 models revealed that the P5Tx tumor wa …
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