Alexander Bondoc · Oncogenic Role of Aberrant EZH2 in Hepatoblastoma.

Follow

From Dr. Alexander Bondoc

Article1 min read·Published Oct 2026

Oncogenic Role of Aberrant EZH2 in Hepatoblastoma.

Part of Hepatoblastoma: Comprehensive Management 20 items

pubmed.ncbi.nlm.nih.gov

Oncogenic Role of Aberrant EZH2 in Hepatoblastoma.

Alexander Bondoc

Hepatoblastoma (HB) is the most common pediatric liver malignancy. However, its cellular origin and molecular drivers remain poorly defined. Using single-nuclear RNA sequencing (snRNA-seq), we identified a proliferative, hepatocyte-derived tumor cell population (cycling HepT) enriched for Enhancer of Zeste Homolog 2 (EZH2) expression, particularly in the aggressive embryonal subtype. Integrative g…

pubmed.ncbi.nlm.nih.gov shows its articles on its own site.

Read the article on pubmed.ncbi.nlm.nih.gov ↗

Article · Oct 2026 · 1 min read

In brief

In brief

Single-nuclear RNA sequencing reveals EZH2 overexpression in proliferative hepatoblastoma tumor cells, particularly in aggressive embryonal subtypes. This epigenetic regulator represents a potential therapeutic target for pediatric liver malignancies with currently limited treatment options.

Written by the GCMD Library team from the article.

Alexander Bondoc

Hepatoblastoma (HB) is the most common pediatric liver malignancy. However, its cellular origin and molecular drivers remain poorly defined. Using single-nuclear RNA sequencing (snRNA-seq), we identified a proliferative, hepatocyte-derived tumor cell population (cycling HepT) enriched for Enhancer of Zeste Homolog 2 (EZH2) expression, particularly in the aggressive embryonal subtype. Integrative g…

Read it at the source ↗

Try

Intelligent Search· scoped to this article · not medical adviceSearch the whole library →

More in this field

Dive deeper → Hepatoblastoma: Comprehensive Management (20 items)

EZH2 is a key component of hepatoblastoma tumor cell growth.

Alexander Bondoc · Published Oct 2026

A developmentally prometastatic niche to hepatoblastoma in neonatal liver mediated by the Cxcl1/Cxcr2 axis

Alexander Bondoc · Published Oct 2026

Quality of Life Outcomes for Patients Who Underwent Conventional Resection and Liver Transplantation for Locally Advanced Hepatoblastoma

Alexander Bondoc · Published Oct 2026

Indocyanine Green Fluorescence for Intraoperative Tumor Identification During Resection of Pediatric and Adolescent Intra-Abdominal Malignancy: A Prospective Multi-Institutional Observational Study

Alexander Bondoc · Published Jun 2026

Investigating the oncogenic role of aberrant EZH2 in hepatoblastoma

Alexander Bondoc · Published Feb 2026

Utilization of Indocyanine Green for Augmentation of Pulmonary Metastases Resection in Pediatric, Adolescent, and Young Adult Sarcoma Patients

Alexander Bondoc · Published Jan 2026

More from this author

Dive deeper → Dr. Alexander Bondoc

Pediatric Liver Transplant: Anatomic, Imaging, and Surgical Considerations-A Report of the Pediatric LI-RADS Working Group, From the AJR Special Series on Critical Anatomy

Alexander Bondoc · Published Oct 2026

Outcomes of Fontan patients undergoing combined heart-liver transplantation in pediatric hospitals across the United States

Alexander Bondoc · Published Oct 2026

Pediatric pancreas transplantation, including total pancreatectomy with islet autotransplantation

Alexander Bondoc · Published Oct 2026

Clinical guideline for the diagnosis and treatment of fibrolamellar carcinoma.

Alexander Bondoc · Published Oct 2026

Customized Postoperative Therapy Improves Bile Drainage in Biliary Atresia: A Single Center Preliminary Report

Alexander Bondoc · Published Oct 2026

Alexander Bondoc · Published Oct 2026