Alessandro de Alarcon · Sirolimus for the treatment of juvenile nasopharyngeal angiofibroma.
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Article1 min read·Published Oct 2026

Sirolimus for the treatment of juvenile nasopharyngeal angiofibroma.

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Article · Oct 2026 · 1 min read

In brief

In brief

This case series reports successful medical management of juvenile nasopharyngeal angiofibroma using sirolimus, an mTOR inhibitor, as an alternative to traditional surgical and radiation approaches. Three patients demonstrated clinical and radiographic improvement with sirolimus therapy, suggesting a potential role for targeted medical treatment in this locally aggressive vascular tumor.

Written by the GCMD Library team from the article.

Alessandro de Alarcon

Juvenile nasopharyngeal angiofibroma (JNA) is a pathologically benign yet locally aggressive and destructive tumor that develops in the choana and nasopharynx. Historical treatment of JNA has included embolization, surgical resection, and radiation. Here, we describe three patients who received therapy with the mTOR inhibitor sirolimus with improvement in clinical symptoms, imaging, and overall we…

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