Chronic Pancreatitis: When Is TPIAT the Operation Left?
Carousel1 min read·Published Oct 2026

Chronic Pancreatitis: When Is TPIAT the Operation Left?

Clinical case: child with recurrent pancreatitis on maxed medical therapy, asking what surgical options remain.
Slide explaining why partial pancreatectomy fails in genetic pancreatic disease due to ongoing mutation damage.
Slide explaining total pancreatectomy removes pain source but causes diabetes due to insulin loss.
Slide explaining TPIAT procedure where islet cells are recovered and transplanted to maintain insulin production.
Slide explaining TPIAT goals: restoring childhood and managing pain in pediatric pancreatic disease.
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Carousel · Oct 2026 · 1 min read

In brief

In brief

Educational carousel reviewing indications for total pancreatectomy with islet autotransplantation (TPIAT) in chronic pancreatitis management. Explores clinical scenarios where this definitive surgical option becomes appropriate when medical management and less invasive interventions have been exhausted.

Written by the GCMD Library team from the carousel.

Slides

6 pages · click to turn to one
Pancreas. A social-media carousel made possible by Cincinnati Children's.
The text on each slide
  1. Pancreas | Clinical Foundations | Made possible by Cincinnati Children's | A child with recurrent pancreatitis since age 3, prescribed opioids by age 5. Medical therapy is maxed out. Endoscopy has nothing left to dilate or drain. | SO WHAT OPERATION IS LEFT? | 1/6
  2. Pancreas | Clinical Foundations | Made possible by Cincinnati Children's | THE REALITY FOR THESE KIDS | Overview of the Surgical Management of Acute and Chronic Pancreatitis in Children Live Event | Juan Pablo Gurria, MD, MSc | Pediatric Surgeon, Division of Pediatric General and Thoracic Surgery, Surgical Director, Pancreas Care Center, Cincinnati Children's | 2/6
  3. Pancreas | Clinical Foundations | Made possible by Cincinnati Children's | WHY NOT JUST TAKE A PIECE | TAKING A PIECE ISN'T ENOUGH | With a genetic cause, taking out part of the pancreas doesn't help. The mutation keeps damaging what's left. | 3/6
  4. Pancreas | Clinical Foundations | Made possible by Cincinnati Children's | THE OPERATION | TAKE OUT THE WHOLE PANCREAS | It takes away the source of the pain. But the pancreas also makes insulin so on its own, removing it would leave the child diabetic. | 4/6
  5. Pancreas | Clinical Foundations | Made possible by Cincinnati Children's | HOW THAT'S SOLVED | TPIAT | Dr. Gurria's team performs a Total Pancreatectomy with Islet Autotransplantation (TPIAT) recovers the child's own islet cells from that pancreas and transplants them back, so the body keeps making its own insulin. | 5/6
  6. Pancreas | Clinical Foundations | Made possible by Cincinnati Children's | THE GOAL | GIVE THEM THEIR CHILDHOOD BACK | TPIAT is great for the child whose whole pancreas is the problem. | Some still need insulin after. The operation is for the pain. | 6/6
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