Who's speaking
- Sophia Schermerhorn — host
Chapters
- 0:00Social Determinants and Pediatric Oncology Survival — Introduction of a Cincinnati Children's study on socioeconomic disadvantage and survival in Wilms tumor, neuroblastoma, and hepatoblastoma, with presentation of key findings and clinical implications.
Key claims
- 0:12Study was a retrospective analysis of 12,000 patients with neuroblastoma, Wilms tumor, and hepatoblastoma from the National Cancer Database — Sophia Schermerhorn
- 0:20Socioeconomic disadvantage score was created for each patient based on median household income and education level in their local communities — Sophia Schermerhorn
- 0:31The most disadvantaged children were more likely to have worse survival for Wilms tumor and neuroblastoma — Sophia Schermerhorn
- 0:37After adjusting for tumor size, grade, treatment, and comorbidities, socioeconomic effects on survival remained present — Sophia Schermerhorn
- 0:44Hazard ratio for socioeconomic disadvantage was 2.02 for Wilms tumor — Sophia Schermerhorn
- 0:44Hazard ratio for socioeconomic disadvantage was 1.29 for hepatoblastoma — Sophia Schermerhorn
- 0:51Pediatric oncology outcomes depend on tumor biology, treatment received, and social determinants of health — Sophia Schermerhorn
- 1:00Identifying socioeconomic risk factors is necessary to close equity gaps and improve survival for all children with solid tumors — Sophia Schermerhorn
Open questions
- What specific mechanisms link socioeconomic disadvantage to worse survival in these pediatric cancers?
- What interventions can effectively address socioeconomic disparities in pediatric oncology outcomes?
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