Who's speaking
- Sovia Skermerhorn — guest
Chapters
- 0:00Study Background and Design — Introduction of the PeaceSOC multi-center retrospective study examining pulmonary relapse in pediatric Ewing sarcoma patients across 19 centers from 2007-2020.
- 0:32Key Findings on Relapse Patterns and Survival — Presentation of survival outcomes stratified by relapse pattern: solitary nodule (73% 3-year survival), multiple nodules (40%), and extrapulmonary disease (23%).
- 0:55Clinical Implications — Discussion of the biological and therapeutic significance of solitary pulmonary relapse and the role of metastasectomy in multimodal treatment.
Key claims
- 0:05Writer et al. published a multi-center retrospective study in the Journal of Pediatric Surgery through PeaceSOC in 2024 — Sovia Skermerhorn
- 0:07PeaceSOC is a network of over 50 centers in North America that work together to improve outcomes in pediatric surgical oncology — Sovia Skermerhorn
- 0:20The study examined patients less than 22 years old with initially localized Ewing sarcoma who developed first pulmonary relapse between 2007 and 2020 across 19 different centers — Sovia Skermerhorn
- 0:32Among 33 patients studied, about 2/3 had relapse limited to the lungs — Sovia Skermerhorn
- 0:32Nearly half of patients with lung-limited relapse had just a solitary pulmonary nodule — Sovia Skermerhorn
- 0:39Patients with solitary pulmonary nodule were more likely to undergo metastasectomy and whole lung radiation — Sovia Skermerhorn
- 0:39Patients with solitary pulmonary nodule had the highest overall three-year survival at 73% — Sovia Skermerhorn
- 0:50Three-year survival for patients with multiple nodules was 40% — Sovia Skermerhorn
- 0:50Three-year survival for patients with extrapulmonary disease was 23% — Sovia Skermerhorn
- 0:57Solitary pulmonary relapse may represent a biologically more favorable type of recurrence — Sovia Skermerhorn
- 0:57Solitary pulmonary relapse is more amenable to achieving meaningful local control — Sovia Skermerhorn
- 0:57Metastasectomy plays an important role as part of multimodal therapy for solitary pulmonary relapse in Ewing sarcoma — Sovia Skermerhorn
Open questions
- Would you offer a metastasectomy for a solitary Ewing relapse at your institution?
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