Educational content from recorded physician discussions — not medical advice. Always talk to your child's care team about your child's situation.
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Suppression of microglial activation with anti-inflammatory drug bindarit enhances neural development in the shunt-treated neonatal hydrocephalus model rat
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Neonatal hydrocephalus is a prevalent neurological condition typically managed through cerebrospinal fluid (CSF) diversion procedures, such as ventriculoperitoneal shunting. Despite surgical intervention, many patients exhibit persistent hy
article · Nov 2026
Early postnatal microglial ablation in the Ccdc39 mouse model reveals adverse effects on brain development and in neonatal hydrocephalus
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Background: Neonatal hydrocephalus is a congenital abnormality resulting in an inflammatory response and microglial cell activation both clinically and in animal models. Previously, we reported a mutation in a motile cilia gene, Ccdc39 that
article · Nov 2026
The Anti-Inflammatory Agent Bindarit Attenuates the Impairment of Neural Development through Suppression of Microglial Activation in a Neonatal Hydrocephalus Mouse Model
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Neonatal hydrocephalus presents with various degrees of neuroinflammation and long-term neurologic deficits in surgically treated patients, provoking a need for additional medical treatment. We previously reported elevated neuroinflammation
article · Nov 2026
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