StayCurrentMD · Journal of Pediatric Article Review: June 2023, AAP Issue
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Podcast13 min·Published Sep 2023Older

Journal of Pediatric Article Review: June 2023, AAP Issue

With Dr. Colin Martin & Dr. Brad Warner & Dr. Andrew Fleming · hosted by Dr. Cecilia Gigena & Dr. Em Tombash & Dr. Todd Ponsky · StayCurrentMD
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What the experts said6 expert statements · 8 host summaries
The ileocecal region may not be important to preserve in short bowel syndrome and may actually be injurious
ClinicalBrad Warner
Administration of a specific bile acid that is more lipophilic and hepatoprotective could be potential therapy for patients with cholestatic liver disease after massive intestinal resection
ClinicalBrad Warner
In clinical practice, surgeons cannot choose which intestinal segment to remove - they must remove what is dead and preserve as much viable bowel as possible
ClinicalBrad Warner
Once NED status was achieved, 10-year overall survival among high-risk hepatoblastoma patients was similar to patients who were not high-risk
ClinicalAndrew Fleming
There is no threshold for disease burden that precludes aggressive pursuit of no-evidence-of-disease status in children with hepatoblastoma
OpinionAndrew Fleming
Having a formal aerodigestive team is the way to ensure esophageal atresia surveillance gets done
OpinionTodd Ponsky
Proximal small bowel resection results in greater oxidative stress in the liver, evidenced by elevated mRNA transcripts for tumor necrosis factor alpha, NADPH oxidase, and glutathione synthase with greater compensatory antioxidant response
Host summaryColin Martin · not cited in answers
46 of 50 hepatoblastoma patients underwent resection using adjuvant techniques including total hepatic vascular exclusion, vascular reconstruction, biliary reconstruction, or en-bloc resection and total hepatectomy with transplantation
Host summaryColin Martin · not cited in answers
82% (41 of 50) of hepatoblastoma patients were able to achieve no-evidence-of-disease (NED) status
Host summaryColin Martin · not cited in answers
14 high-risk hepatoblastoma patients underwent a median of 2.5 pulmonary metastasectomies (7 for unilateral disease, 7 for bilateral disease) with a median of 4.5 nodules resected
Host summaryEm Tombash · not cited in answers
5 high-risk hepatoblastoma patients relapsed and 3 of them were saved; NED status was inversely correlated with 5-year mortality
Host summaryEm Tombash · not cited in answers
The esophageal atresia surveillance survey had a 77% response rate from 181 physicians at 19 institutions
Host summaryColin Martin · not cited in answers
Only 36% of institutions perform routine upper GI endoscopy in esophageal atresia patients regardless of symptoms, despite evidence showing these patients should be surveilled
Host summaryColin Martin · not cited in answers
Without proper surveillance, esophageal atresia patients could be at risk for esophageal cancer and chronic dysmotility as they survive into adulthood
Host summaryColin Martin · not cited in answers