Journal of Pediatric Surgery Article Review: June 2022, AAP Issue
With Dr. Nicole Chandler & Dr. Todd Ponsky and Biran Modi & Dr. Marcus Malik · hosted by Dr. Ellen Incisco and M. Tom Bash · StayCurrentMD
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What the experts said
NAT was higher after the lockdown, not during the lockdown
During times of public health crises, it's important to maintain systems of protection for children
Management of metastatic hepatoblastoma continues to pose significant treatment challenges
PSORC (Pediatric Surgical Oncology Research Collaborative) is a multi-institutional consortium of North American pediatric surgeons focused on advancing care of children with cancer
PSORC was founded because there was a need to amalgamate data from multiple institutions to better study surgical questions in pediatric cancer
Image-guided localization techniques varied significantly among institutions but all were wildly successful, showing that experience is probably more important than the actual technique itself
Pediatric intestinal failure was defined as requirement of parenteral nutrition for 60 days or more at any time, with diagnosis before 8 years of age
The hypothesis was that chronic pediatric intestinal failure would delay puberty and potentially dull the sharp spike of puberty in terms of peak height velocity
There is a high incidence of short stature in chronic intestinal failure
The finding that short stature is not because kids are missing out on pubertal timing and peak height velocity suggests we need to do a better job at setting them up to go into puberty with working on their height and linear growth
The Midwest Pediatric Surgery Research Consortium (MWPSC) was established by departments of Pediatric Surgery from 11 children's hospitals
The NAT study used historical patterns captured by trauma registries to predict what the volume should have been during the initial COVID time period and compared that to observed rates
Initially non-accidental trauma rates dropped a little bit, but after that the rate increased above what they had expected during the stay at home orders
Patients disproportionately affected were older kids who were older than 5 years who would most commonly be in school, minority children, and lower socioeconomic groups as determined by the social vulnerability index
CDC Social Vulnerability Index was uniquely created to see neighborhood's vulnerability during times of crises
One has to be careful not to make too strong of conclusions based on any data when it's related to simply ICD 10 codes, regardless of how many institutions and how long the evaluation period was
There are very few cell lines available to study hepatoblastoma, and a number of cell lines touted to be hepatoblastoma are actually hepatocellular carcinoma
The new hepatoblastoma cell line was created by injecting labeled cells into mouse tail vein, harvesting lung metastases, culturing surviving cells, and repeating the process until establishing a reliably metastatic cell line
Compared to the original human cell line, the new cell line exhibited increased tumorigenicity, invasiveness, and increased resistance to chemotherapy
The most common localization techniques for small pulmonary nodules were wire and methylene blue dye, followed by methylene blue dye only
There was no difference in successful IR localization or successful resection of pulmonary nodules when comparing different localization techniques
Peak height velocity occurred at significantly younger ages for both males and females with intestinal failure
Puberty onset occurred significantly earlier compared to established norms for males, meaning they reached pubertal onset earlier than the CDC 50th percentile