# Pediatric Oncology Surgery — GCMD Library living collection

Updated: n/a · 4 episodes · 44 cited statements

## Episodes
### Wilms Tumor
- [Wilms tumor management: comparing COG and SIOP treatment approaches](https://library.globalcastmd.com/watch/wilms-tumor-management-comparing-cog-and-siop-treatment-approaches-16868) — podcast · 4:07 · [machine version](https://library.globalcastmd.com/watch/wilms-tumor-management-comparing-cog-and-siop-treatment-approaches-16868.md)
- [VTE prophylaxis, fertility preservation, and nephron-sparing surgery in pediatric patients](https://library.globalcastmd.com/watch/vte-prophylaxis-fertility-preservation-and-nephron-sparing-surgery-in-pediatric-16866) — podcast · 4:04 · [machine version](https://library.globalcastmd.com/watch/vte-prophylaxis-fertility-preservation-and-nephron-sparing-surgery-in-pediatric-16866.md)

### Chest Wall Tumors
- [Pediatric chest wall reconstruction for osteosarcoma: case-based approach](https://library.globalcastmd.com/watch/pediatric-chest-wall-reconstruction-for-osteosarcoma-case-based-approach-16870) — podcast · 5:32 · [machine version](https://library.globalcastmd.com/watch/pediatric-chest-wall-reconstruction-for-osteosarcoma-case-based-approach-16870.md)

### Oncofertility
- [Pediatric oncofertility: preserving reproductive futures for childhood cancer survivors](https://library.globalcastmd.com/watch/pediatric-oncofertility-preserving-reproductive-futures-for-childhood-cancer-sur-16858) — podcast · 13:01 · [machine version](https://library.globalcastmd.com/watch/pediatric-oncofertility-preserving-reproductive-futures-for-childhood-cancer-sur-16858.md)

## Chapters
- [0:00](https://library.globalcastmd.com/watch/pediatric-oncofertility-preserving-reproductive-futures-for-childhood-cancer-sur-16858?t=0) Introduction and rationale for pediatric fertility preservation (Ep 4)
- [2:14](https://library.globalcastmd.com/watch/pediatric-oncofertility-preserving-reproductive-futures-for-childhood-cancer-sur-16858?t=134) Available preservation options and risk assessment (Ep 4)
- [3:48](https://library.globalcastmd.com/watch/pediatric-oncofertility-preserving-reproductive-futures-for-childhood-cancer-sur-16858?t=228) Program history and patient volume (Ep 4)
- [6:09](https://library.globalcastmd.com/watch/pediatric-oncofertility-preserving-reproductive-futures-for-childhood-cancer-sur-16858?t=369) Ovarian tissue cryopreservation procedure and processing (Ep 4)
- [7:33](https://library.globalcastmd.com/watch/pediatric-oncofertility-preserving-reproductive-futures-for-childhood-cancer-sur-16858?t=453) Ovarian tissue transplantation: history and current outcomes (Ep 4)
- [9:43](https://library.globalcastmd.com/watch/pediatric-oncofertility-preserving-reproductive-futures-for-childhood-cancer-sur-16858?t=583) Bioprosthetic ovary research and ovarian microenvironment mapping (Ep 4)
- [0:16](https://library.globalcastmd.com/watch/vte-prophylaxis-fertility-preservation-and-nephron-sparing-surgery-in-pediatric-16866?t=16) VTE prophylaxis in high-risk pediatric trauma patients (Ep 2)
- [1:44](https://library.globalcastmd.com/watch/vte-prophylaxis-fertility-preservation-and-nephron-sparing-surgery-in-pediatric-16866?t=104) Ovarian tissue cryopreservation outcomes in childhood cancer survivors (Ep 2)
- [2:47](https://library.globalcastmd.com/watch/vte-prophylaxis-fertility-preservation-and-nephron-sparing-surgery-in-pediatric-16866?t=167) Nephron-sparing surgery versus radical nephrectomy for unilateral Wilms tumor (Ep 2)
- [3:47](https://library.globalcastmd.com/watch/vte-prophylaxis-fertility-preservation-and-nephron-sparing-surgery-in-pediatric-16866?t=227) Closing remarks (Ep 2)
- [0:00](https://library.globalcastmd.com/watch/wilms-tumor-management-comparing-cog-and-siop-treatment-approaches-16868?t=0) Case presentation and international treatment variation (Ep 1)
- [1:17](https://library.globalcastmd.com/watch/wilms-tumor-management-comparing-cog-and-siop-treatment-approaches-16868?t=77) Post-resection pathology and loss of heterozygosity significance (Ep 1)
- [2:33](https://library.globalcastmd.com/watch/wilms-tumor-management-comparing-cog-and-siop-treatment-approaches-16868?t=153) Modified scenario with loss of heterozygosity present (Ep 1)
- [3:30](https://library.globalcastmd.com/watch/wilms-tumor-management-comparing-cog-and-siop-treatment-approaches-16868?t=210) Summary of treatment approaches and genetic markers (Ep 1)
- [0:00](https://library.globalcastmd.com/watch/pediatric-chest-wall-reconstruction-for-osteosarcoma-case-based-approach-16870?t=0) Case presentation: 14-year-old with T6 osteosarcoma and cord compression (Ep 3)
- [1:32](https://library.globalcastmd.com/watch/pediatric-chest-wall-reconstruction-for-osteosarcoma-case-based-approach-16870?t=92) Surgical technique: combined resection and chest wall reconstruction (Ep 3)
- [3:48](https://library.globalcastmd.com/watch/pediatric-chest-wall-reconstruction-for-osteosarcoma-case-based-approach-16870?t=228) Post-operative imaging and disease recurrence (Ep 3)
- [4:26](https://library.globalcastmd.com/watch/pediatric-chest-wall-reconstruction-for-osteosarcoma-case-based-approach-16870?t=266) Complications and future directions (Ep 3)

## Statements
Every statement is attributed, typed, and timestamped; the link is the citation.
- The team has about 10 years of experience with chest wall reconstructions. — Margaret Mutch (clinical) [Ep 3 · 0:16](https://library.globalcastmd.com/watch/pediatric-chest-wall-reconstruction-for-osteosarcoma-case-based-approach-16870?t=16)
- The patient had an incomplete cord injury with absent lower limb reflexes and altered motor and sensation below the level of T6. — Margaret Mutch (clinical) [Ep 3 · 0:27](https://library.globalcastmd.com/watch/pediatric-chest-wall-reconstruction-for-osteosarcoma-case-based-approach-16870?t=27)
- The patient underwent emergency posterior laminectomy and partial tumor debulking between the levels of T3 and T7 for cord decompression. — Margaret Mutch (clinical) [Ep 3 · 0:42](https://library.globalcastmd.com/watch/pediatric-chest-wall-reconstruction-for-osteosarcoma-case-based-approach-16870?t=42)
- Anterior thoracotomy removed a PET avid lesion that confirmed aggressive osteosarcoma replacing a lymph node. — Margaret Mutch (clinical) [Ep 3 · 1:17](https://library.globalcastmd.com/watch/pediatric-chest-wall-reconstruction-for-osteosarcoma-case-based-approach-16870?t=77)
- Most of the reconstruction needs to be tailored to the needs of each individual, location and size of defects. — Margaret Mutch (opinion) [Ep 3 · 1:32](https://library.globalcastmd.com/watch/pediatric-chest-wall-reconstruction-for-osteosarcoma-case-based-approach-16870?t=92)
- A lot of the literature on chest wall reconstruction is coming from adults. — Margaret Mutch (clinical) [Ep 3 · 1:55](https://library.globalcastmd.com/watch/pediatric-chest-wall-reconstruction-for-osteosarcoma-case-based-approach-16870?t=115)
- Spinal surgeons removed all vertebral bodies between T4 and T7 and inserted a cage, and the thoracic team resected ribs 4 to 7. — Margaret Mutch (clinical) [Ep 3 · 2:06](https://library.globalcastmd.com/watch/pediatric-chest-wall-reconstruction-for-osteosarcoma-case-based-approach-16870?t=126)
- During surgery, a tumor thrombus was found in the azygos which extended into the SVC. — Margaret Mutch (clinical) [Ep 3 · 2:28](https://library.globalcastmd.com/watch/pediatric-chest-wall-reconstruction-for-osteosarcoma-case-based-approach-16870?t=148)
- The team tends to use resorbable and biosynthetic materials to do the reconstruction. — Margaret Mutch (clinical) [Ep 3 · 2:44](https://library.globalcastmd.com/watch/pediatric-chest-wall-reconstruction-for-osteosarcoma-case-based-approach-16870?t=164)
- Two systems are available in Australia for resorbable plates: one by Stryker and one by KLS. — Margaret Mutch (clinical) [Ep 3 · 2:51](https://library.globalcastmd.com/watch/pediatric-chest-wall-reconstruction-for-osteosarcoma-case-based-approach-16870?t=171)
- Permacol was placed on top of the implant, and a latissimus dorsi pedicled flap was used to cover the Permacol. — Margaret Mutch (clinical) [Ep 3 · 3:14](https://library.globalcastmd.com/watch/pediatric-chest-wall-reconstruction-for-osteosarcoma-case-based-approach-16870?t=194)
- Permacol is made of a porcine dermal collagen matrix. — Margaret Mutch (clinical) [Ep 3 · 3:29](https://library.globalcastmd.com/watch/pediatric-chest-wall-reconstruction-for-osteosarcoma-case-based-approach-16870?t=209)
- The delta plates or sonic weld system are polylactide and polyglycolide and polydioxanone plates. — Margaret Mutch (clinical) [Ep 3 · 3:32](https://library.globalcastmd.com/watch/pediatric-chest-wall-reconstruction-for-osteosarcoma-case-based-approach-16870?t=212)
- The resorbable plates have a strength of 78% at 2 months and 50% at 6 months. — Margaret Mutch (clinical) [Ep 3 · 3:47](https://library.globalcastmd.com/watch/pediatric-chest-wall-reconstruction-for-osteosarcoma-case-based-approach-16870?t=227)
- The patient had a relapse 18 months following the surgery close to his sternum. — Margaret Mutch (clinical) [Ep 3 · 4:05](https://library.globalcastmd.com/watch/pediatric-chest-wall-reconstruction-for-osteosarcoma-case-based-approach-16870?t=245)
- The patient is currently having adjuvant chemotherapy. — Margaret Mutch (clinical) [Ep 3 · 4:22](https://library.globalcastmd.com/watch/pediatric-chest-wall-reconstruction-for-osteosarcoma-case-based-approach-16870?t=262)
- There was early postoperative infection in one patient which was treated with IV antibiotics. — Margaret Mutch (clinical) [Ep 3 · 4:31](https://library.globalcastmd.com/watch/pediatric-chest-wall-reconstruction-for-osteosarcoma-case-based-approach-16870?t=271)
- There were sterile seromas in two patients in the early stages, one at 2 months and one at 8 months. — Margaret Mutch (clinical) [Ep 3 · 4:36](https://library.globalcastmd.com/watch/pediatric-chest-wall-reconstruction-for-osteosarcoma-case-based-approach-16870?t=276)
- Loss of control over reproductive future is one of the top quality of life parameters of importance for childhood cancer survivors — Monica Laronda (clinical) [Ep 4 · 1:10](https://library.globalcastmd.com/watch/pediatric-oncofertility-preserving-reproductive-futures-for-childhood-cancer-sur-16858?t=70)
- Most cancer survivors prefer to have a biological offspring over a gamete donation or a gestational carrier — Monica Laronda (epidemiological) [Ep 4 · 1:23](https://library.globalcastmd.com/watch/pediatric-oncofertility-preserving-reproductive-futures-for-childhood-cancer-sur-16858?t=83)
- Parents want fertility preservation options presented for their children regardless of their infertility risk or prognosis, based on Lurie Children's own research — Monica Laronda (epidemiological) [Ep 4 · 1:52](https://library.globalcastmd.com/watch/pediatric-oncofertility-preserving-reproductive-futures-for-childhood-cancer-sur-16858?t=112)
- Patient risk for premature gonadal insufficiency is determined by calculating cumulative cyclophosphamide equivalent dose, imminent surgery, chemotherapy with alkylating agents, or radiation therapy — Monica Laronda (clinical) [Ep 4 · 3:04](https://library.globalcastmd.com/watch/pediatric-oncofertility-preserving-reproductive-futures-for-childhood-cancer-sur-16858?t=184)
- A 12-year-old receiving 10 gray of radiation can undergo menopause at approximately 19.5 years old — Monica Laronda (clinical) [Ep 4 · 3:48](https://library.globalcastmd.com/watch/pediatric-oncofertility-preserving-reproductive-futures-for-childhood-cancer-sur-16858?t=228)
- Life expectancy can be reduced by 2 years from additional comorbidities resulting from lack of gonadal hormones after premature menopause — Monica Laronda (epidemiological) [Ep 4 · 3:57](https://library.globalcastmd.com/watch/pediatric-oncofertility-preserving-reproductive-futures-for-childhood-cancer-sur-16858?t=237)
- Lurie Children's fertility program first started collaborating with Northwestern University Oncofertility Consortium in 2011 — Monica Laronda (clinical) [Ep 4 · 4:52](https://library.globalcastmd.com/watch/pediatric-oncofertility-preserving-reproductive-futures-for-childhood-cancer-sur-16858?t=292)
- Lurie Children's has performed over 200 ovarian tissue cryopreservation procedures and approximately 170 testicular tissue cryopreservation procedures — Monica Laronda (epidemiological) [Ep 4 · 5:36](https://library.globalcastmd.com/watch/pediatric-oncofertility-preserving-reproductive-futures-for-childhood-cancer-sur-16858?t=336)
- Approximately 25% of ovarian tissue cryopreservation patients are referrals from outside Lurie Children's Hospital — Monica Laronda (epidemiological) [Ep 4 · 5:46](https://library.globalcastmd.com/watch/pediatric-oncofertility-preserving-reproductive-futures-for-childhood-cancer-sur-16858?t=346)
- Ovarian tissue cryopreservation is performed with a unilateral oophorectomy, and the other ovary compensates and maintains the same level of hormones — Monica Laronda (clinical) [Ep 4 · 6:09](https://library.globalcastmd.com/watch/pediatric-oncofertility-preserving-reproductive-futures-for-childhood-cancer-sur-16858?t=369)
- The remaining ovary can release more eggs when stimulated for assisted reproductive technologies, and there is little difference in age at menopause — Monica Laronda (clinical) [Ep 4 · 6:25](https://library.globalcastmd.com/watch/pediatric-oncofertility-preserving-reproductive-futures-for-childhood-cancer-sur-16858?t=385)
- The first successful ovarian tissue cryopreservation and transplantation in a large animal model was done in sheep in 1994 — Monica Laronda (clinical) [Ep 4 · 7:45](https://library.globalcastmd.com/watch/pediatric-oncofertility-preserving-reproductive-futures-for-childhood-cancer-sur-16858?t=465)
- The first orthotopic human transplant was performed in the pelvic wall in 2000 — Monica Laronda (clinical) [Ep 4 · 7:55](https://library.globalcastmd.com/watch/pediatric-oncofertility-preserving-reproductive-futures-for-childhood-cancer-sur-16858?t=475)
- The first live births following ovarian autotransplant from frozen-thawed tissue happened between 2004 and 2006 in Israel — Monica Laronda (clinical) [Ep 4 · 8:12](https://library.globalcastmd.com/watch/pediatric-oncofertility-preserving-reproductive-futures-for-childhood-cancer-sur-16858?t=492)
- Hormone production after ovarian tissue transplantation lasts an average of 2 to 5 years and has been reported to exceed 12 years — Monica Laronda (clinical) [Ep 4 · 8:36](https://library.globalcastmd.com/watch/pediatric-oncofertility-preserving-reproductive-futures-for-childhood-cancer-sur-16858?t=516)
- For many cancer patients, there is a possibility of reintroducing cancer cells from their tissue during autotransplantation — Monica Laronda (clinical) [Ep 4 · 8:42](https://library.globalcastmd.com/watch/pediatric-oncofertility-preserving-reproductive-futures-for-childhood-cancer-sur-16858?t=522)
- Green fluorescent protein expressing follicles transplanted in a 3D printed scaffold into a mouse without this protein spontaneously produced pups expressing the green fluorescent protein, proving the eggs came from the bioprosthetic ovary — Monica Laronda (clinical) [Ep 4 · 9:49](https://library.globalcastmd.com/watch/pediatric-oncofertility-preserving-reproductive-futures-for-childhood-cancer-sur-16858?t=589)
- Infants with very young ovaries are significantly different in their makeup of different cell types compared to prepubertal and postpubertal ovaries from slightly older individuals — Monica Laronda (clinical) [Ep 4 · 10:30](https://library.globalcastmd.com/watch/pediatric-oncofertility-preserving-reproductive-futures-for-childhood-cancer-sur-16858?t=630)
- The Laronda lab found 82 different matrosome proteins in the ovary, with 42 significantly differentially expressed across different compartments — Monica Laronda (clinical) [Ep 4 · 10:59](https://library.globalcastmd.com/watch/pediatric-oncofertility-preserving-reproductive-futures-for-childhood-cancer-sur-16858?t=659)
- The lab discovered 11 matrosome proteins that had not yet been previously identified within the ovary — Monica Laronda (clinical) [Ep 4 · 11:20](https://library.globalcastmd.com/watch/pediatric-oncofertility-preserving-reproductive-futures-for-childhood-cancer-sur-16858?t=680)
- The density of extracellular matrix protein matched the rigidity curve of atomic force microscopy analysis, suggesting the rigidity of the ovary might be in part due to the amount of extracellular matrix proteins in a region — Monica Laronda (clinical) [Ep 4 · 11:56](https://library.globalcastmd.com/watch/pediatric-oncofertility-preserving-reproductive-futures-for-childhood-cancer-sur-16858?t=716)
- European colleagues would offer chemotherapy without biopsy for Wilms tumor, while North American/COG sites would perform resection and diagnosis first. (guideline) [Ep 1 · 0:47](https://library.globalcastmd.com/watch/wilms-tumor-management-comparing-cog-and-siop-treatment-approaches-16868?t=47)
- Doxorubicin should be added when there is loss of heterozygosity at 1P and 16Q because that shows higher recurrence. — Bargaba Mulaudi (clinical) [Ep 1 · 2:18](https://library.globalcastmd.com/watch/wilms-tumor-management-comparing-cog-and-siop-treatment-approaches-16868?t=138)
- For surgeons, there will be more waiting for biology results before determining if chemotherapy is needed, affecting timing of port placement. (clinical) [Ep 1 · 2:43](https://library.globalcastmd.com/watch/wilms-tumor-management-comparing-cog-and-siop-treatment-approaches-16868?t=163)
- It is not accurate to tell families that children under 2 years of age with tumors under 550g will not need chemotherapy, because biology studies may require adding chemotherapy if loss of heterozygosity at 1P16Q is present. — Bargaba Mulaudi (clinical) [Ep 1 · 2:56](https://library.globalcastmd.com/watch/wilms-tumor-management-comparing-cog-and-siop-treatment-approaches-16868?t=176)
- Even in stage 1 favorable histology, if loss of heterozygosity is present, chemotherapy is still added. — Bargaba Mulaudi (clinical) [Ep 1 · 3:26](https://library.globalcastmd.com/watch/wilms-tumor-management-comparing-cog-and-siop-treatment-approaches-16868?t=206)

## Host summaries
Recaps by a host of what the experts said — not the host's own clinical position.
- Radio guided occult lesion localization using technetium 99 was performed. — Lizzy Lee summarizes what Dr. Margaret Mutch said [Ep 3 · 1:12](https://library.globalcastmd.com/watch/pediatric-chest-wall-reconstruction-for-osteosarcoma-case-based-approach-16870?t=72)
- There is a lack of clear evidence-based guidelines for reconstructive materials. — Lizzy Lee summarizes what Dr. Margaret Mutch said [Ep 3 · 1:45](https://library.globalcastmd.com/watch/pediatric-chest-wall-reconstruction-for-osteosarcoma-case-based-approach-16870?t=105)
- The priority for reconstruction is long-term durability, aesthetics, function, and accommodating future growth. — Lizzy Lee summarizes what Dr. Margaret Mutch said [Ep 3 · 1:45](https://library.globalcastmd.com/watch/pediatric-chest-wall-reconstruction-for-osteosarcoma-case-based-approach-16870?t=105)
- Instead of using screws packaged with the plates, they used a K-wire drill to drill through the remaining ribs and proline sutures to secure the implant. — Lizzy Lee summarizes what Dr. Margaret Mutch said [Ep 3 · 3:05](https://library.globalcastmd.com/watch/pediatric-chest-wall-reconstruction-for-osteosarcoma-case-based-approach-16870?t=185)
- Dr. Matt Nartin performed further chest wall reconstruction excising the entire sternum, costochondral cartilages, and anterior ribs and replaced it with a cement mesh. — Lizzy Lee summarizes what Dr. Margaret Mutch said [Ep 3 · 4:12](https://library.globalcastmd.com/watch/pediatric-chest-wall-reconstruction-for-osteosarcoma-case-based-approach-16870?t=252)
- Both patients with sterile seromas were treated with IR drainage. — Lizzy Lee summarizes what Dr. Margaret Mutch said [Ep 3 · 4:42](https://library.globalcastmd.com/watch/pediatric-chest-wall-reconstruction-for-osteosarcoma-case-based-approach-16870?t=282)
- There was one case of minor scoliosis on follow-up, which is being followed by the spinal team and so far has not needed intervention. — Lizzy Lee summarizes what Dr. Margaret Mutch said [Ep 3 · 4:45](https://library.globalcastmd.com/watch/pediatric-chest-wall-reconstruction-for-osteosarcoma-case-based-approach-16870?t=285)
- Chest wall reconstruction in children is a complex procedure and should be tailored to the individual patient. — Lizzy Lee summarizes what Dr. Margaret Mutch said [Ep 3 · 4:52](https://library.globalcastmd.com/watch/pediatric-chest-wall-reconstruction-for-osteosarcoma-case-based-approach-16870?t=292)
- Bioengineering of tissue replacement and 3D printing may be the way of the future in chest wall reconstructions. — Lizzy Lee summarizes what Dr. Margaret Mutch said [Ep 3 · 5:17](https://library.globalcastmd.com/watch/pediatric-chest-wall-reconstruction-for-osteosarcoma-case-based-approach-16870?t=317)
- Cancer treatments can cause gonadal failure, limiting or destroying the patient's ability to produce offspring in the future — The host summarizes what Dr. Monica Laronda said [Ep 4 · 0:53](https://library.globalcastmd.com/watch/pediatric-oncofertility-preserving-reproductive-futures-for-childhood-cancer-sur-16858?t=53)
- ASCO guidelines underscore the importance of discussing with newly diagnosed cancer patients that their future fertility may be affected by cancer treatments — The host summarizes what Dr. Monica Laronda said [Ep 4 · 1:31](https://library.globalcastmd.com/watch/pediatric-oncofertility-preserving-reproductive-futures-for-childhood-cancer-sur-16858?t=91)
- Fertility preservation is important for any child at risk for premature gonadal insufficiency, including Turner syndrome and mixed gonadal dysgenesis, not just cancer patients — The host summarizes what Dr. Monica Laronda said [Ep 4 · 2:02](https://library.globalcastmd.com/watch/pediatric-oncofertility-preserving-reproductive-futures-for-childhood-cancer-sur-16858?t=122)
- Children with ovaries can undergo ovarian stimulation and oocyte retrieval if they've gone through puberty, or ovarian tissue cryopreservation for pediatric, adolescent, and young adult patients — The host summarizes what Dr. Monica Laronda said [Ep 4 · 2:31](https://library.globalcastmd.com/watch/pediatric-oncofertility-preserving-reproductive-futures-for-childhood-cancer-sur-16858?t=151)
- Children with testes can bank sperm if they've gone through puberty or opt for testicular tissue cryopreservation — The host summarizes what Dr. Monica Laronda said [Ep 4 · 2:46](https://library.globalcastmd.com/watch/pediatric-oncofertility-preserving-reproductive-futures-for-childhood-cancer-sur-16858?t=166)
- A normal ovary has about 300,000 follicles at the time of birth, declining steadily until menopause around age 50 — The host summarizes what Dr. Monica Laronda said [Ep 4 · 3:27](https://library.globalcastmd.com/watch/pediatric-oncofertility-preserving-reproductive-futures-for-childhood-cancer-sur-16858?t=207)
- The first patient was enrolled in March 2011 and underwent ovarian tissue cryopreservation — The host summarizes what Dr. Monica Laronda said [Ep 4 · 5:03](https://library.globalcastmd.com/watch/pediatric-oncofertility-preserving-reproductive-futures-for-childhood-cancer-sur-16858?t=303)
- The program opened for testicular tissue cryopreservation in 2015 — The host summarizes what Dr. Monica Laronda said [Ep 4 · 5:10](https://library.globalcastmd.com/watch/pediatric-oncofertility-preserving-reproductive-futures-for-childhood-cancer-sur-16858?t=310)
- When able, laparoscopic oophorectomy is done at the time of another required procedure such as port placement to decrease the number of times the patient is under general anesthesia — The host summarizes what Dr. Monica Laronda said [Ep 4 · 6:33](https://library.globalcastmd.com/watch/pediatric-oncofertility-preserving-reproductive-futures-for-childhood-cancer-sur-16858?t=393)
- There are approximately 140 reported live births from ovarian tissue autotransplantation — The host summarizes what Dr. Monica Laronda said [Ep 4 · 8:27](https://library.globalcastmd.com/watch/pediatric-oncofertility-preserving-reproductive-futures-for-childhood-cancer-sur-16858?t=507)
- The rate of autotransplantation for recipients who have restored fertility is between 20% and 40% — The host summarizes what Dr. Monica Laronda said [Ep 4 · 8:30](https://library.globalcastmd.com/watch/pediatric-oncofertility-preserving-reproductive-futures-for-childhood-cancer-sur-16858?t=510)
- The Laronda lab developed a 3D printed scaffold composed of 10% gelatin and were able to grow healthy oocytes from mice — The host summarizes what Dr. Monica Laronda said [Ep 4 · 9:43](https://library.globalcastmd.com/watch/pediatric-oncofertility-preserving-reproductive-futures-for-childhood-cancer-sur-16858?t=583)
- Lurie Children's has received a HubMap consortium grant and is now a contributing site generating a normal human ovary atlas describing the ovary microenvironment across development — The host summarizes what Dr. Monica Laronda said [Ep 4 · 10:18](https://library.globalcastmd.com/watch/pediatric-oncofertility-preserving-reproductive-futures-for-childhood-cancer-sur-16858?t=618)
- EMILIN1 protein was identified as potentially influencing follicular genesis — The host summarizes what Dr. Monica Laronda said [Ep 4 · 11:26](https://library.globalcastmd.com/watch/pediatric-oncofertility-preserving-reproductive-futures-for-childhood-cancer-sur-16858?t=686)
- Pediatric trauma patients are at high risk for developing venous thromboembolism. — Lizzy Lee summarizes what Dr. Alex Halpern said [Ep 2 · 1:02](https://library.globalcastmd.com/watch/vte-prophylaxis-fertility-preservation-and-nephron-sparing-surgery-in-pediatric-16866?t=62)
- The Wita et al. cohort study was conducted from 2019 to 2022 in eight pediatric trauma centers and included patients younger than 18 years old. — Lizzy Lee summarizes what Dr. Alex Halpern said [Ep 2 · 1:09](https://library.globalcastmd.com/watch/vte-prophylaxis-fertility-preservation-and-nephron-sparing-surgery-in-pediatric-16866?t=69)
- Among 460 high-risk pediatric trauma patients, more than half received chemical VTE prophylaxis. — Lizzy Lee summarizes what Dr. Alex Halpern said [Ep 2 · 1:18](https://library.globalcastmd.com/watch/vte-prophylaxis-fertility-preservation-and-nephron-sparing-surgery-in-pediatric-16866?t=78)
- Delaying chemical VTE prophylaxis beyond 24 hours of hospital arrival increases the risk of blood clots in high-risk pediatric trauma patients. — Lizzy Lee summarizes what Dr. Alex Halpern said [Ep 2 · 1:25](https://library.globalcastmd.com/watch/vte-prophylaxis-fertility-preservation-and-nephron-sparing-surgery-in-pediatric-16866?t=85)
- VTE prophylaxis is safe and effective for pediatric trauma patients and should be started within 24 hours of admission. — Lizzy Lee summarizes what Dr. Alex Halpern said [Ep 2 · 1:32](https://library.globalcastmd.com/watch/vte-prophylaxis-fertility-preservation-and-nephron-sparing-surgery-in-pediatric-16866?t=92)
- Gillielli et al. performed a systematic retrospective review, initially reviewing 104 abstracts and 34 full-text articles, ultimately including 12 studies. — Alex Halpern summarizing a resource [Ep 2 · 2:04](https://library.globalcastmd.com/watch/vte-prophylaxis-fertility-preservation-and-nephron-sparing-surgery-in-pediatric-16866?t=124)
- Ovarian tissue cryopreservation was performed in 501 patients, with 5.9% undergoing ovarian tissue transplantation. — Alex Halpern summarizing a resource [Ep 2 · 2:16](https://library.globalcastmd.com/watch/vte-prophylaxis-fertility-preservation-and-nephron-sparing-surgery-in-pediatric-16866?t=136)
- After ovarian tissue transplantation, 33% of patients were able to become pregnant. — Alex Halpern summarizing a resource [Ep 2 · 2:27](https://library.globalcastmd.com/watch/vte-prophylaxis-fertility-preservation-and-nephron-sparing-surgery-in-pediatric-16866?t=147)
- Ovarian tissue cryopreservation has advantages for pediatric cancer patients but needs further study. — Alex Halpern summarizing a resource [Ep 2 · 2:33](https://library.globalcastmd.com/watch/vte-prophylaxis-fertility-preservation-and-nephron-sparing-surgery-in-pediatric-16866?t=153)
- The Lee et al. systematic review and meta-analysis from Chongqing, China evaluated efficacy and long-term renal function after nephron-sparing surgery in patients with unilateral Wilms tumor. — Cecilia Gigena summarizes what Dr. Alex Halpern said [Ep 2 · 3:09](https://library.globalcastmd.com/watch/vte-prophylaxis-fertility-preservation-and-nephron-sparing-surgery-in-pediatric-16866?t=189)
- The meta-analysis included 26 studies. — Cecilia Gigena summarizes what Dr. Alex Halpern said [Ep 2 · 3:25](https://library.globalcastmd.com/watch/vte-prophylaxis-fertility-preservation-and-nephron-sparing-surgery-in-pediatric-16866?t=205)
- Nephron-sparing surgery increased glomerular filtration rate after surgery compared to radical nephrectomy. — Cecilia Gigena summarizes what Dr. Alex Halpern said [Ep 2 · 3:25](https://library.globalcastmd.com/watch/vte-prophylaxis-fertility-preservation-and-nephron-sparing-surgery-in-pediatric-16866?t=205)
- Nephron-sparing surgery showed no significant differences in overall survival, recurrences, hypertension, or renal dysfunction compared to radical nephrectomy for unilateral Wilms tumor. — Cecilia Gigena summarizes what Dr. Alex Halpern said [Ep 2 · 3:37](https://library.globalcastmd.com/watch/vte-prophylaxis-fertility-preservation-and-nephron-sparing-surgery-in-pediatric-16866?t=217)
- The case tumor was stage 2 Wilms tumor because it involves the renal sinus and lymphovascular spaces, with overall favorable histology. — Lizzy Lee summarizing the discussion [Ep 1 · 1:34](https://library.globalcastmd.com/watch/wilms-tumor-management-comparing-cog-and-siop-treatment-approaches-16868?t=94)
- Loss of heterozygosity is the loss of genetic diversity in tumor cells and in Wilms tumor can indicate more aggressive disease. — Lizzy Lee summarizing the discussion [Ep 1 · 1:54](https://library.globalcastmd.com/watch/wilms-tumor-management-comparing-cog-and-siop-treatment-approaches-16868?t=114)
- Gain of 1Q refers to an extra copy of a section of chromosome 1, which is linked to worse outcomes in some cancers. — Lizzy Lee summarizing the discussion [Ep 1 · 2:02](https://library.globalcastmd.com/watch/wilms-tumor-management-comparing-cog-and-siop-treatment-approaches-16868?t=122)
- Children's Oncology Group updates state that adverse biologic factors are associated with worse prognosis in stage 2 patients, but not in stage 1 favorable histology Wilms tumor patients. — Lizzy Lee summarizing the discussion [Ep 1 · 3:15](https://library.globalcastmd.com/watch/wilms-tumor-management-comparing-cog-and-siop-treatment-approaches-16868?t=195)
- The North American Children's Oncology Group approach often involves immediate surgery for Wilms tumor. — Lizzy Lee summarizing the discussion [Ep 1 · 3:30](https://library.globalcastmd.com/watch/wilms-tumor-management-comparing-cog-and-siop-treatment-approaches-16868?t=210)
- The European Society of Pediatric Oncology approach typically starts with chemotherapy before surgery for Wilms tumor. — Lizzy Lee summarizing the discussion [Ep 1 · 3:30](https://library.globalcastmd.com/watch/wilms-tumor-management-comparing-cog-and-siop-treatment-approaches-16868?t=210)
- Genetic markers like loss of heterozygosity at specific chromosomes can indicate higher risk of cancer recurrence and guide decisions about adding chemotherapy. — Lizzy Lee summarizing the discussion [Ep 1 · 3:49](https://library.globalcastmd.com/watch/wilms-tumor-management-comparing-cog-and-siop-treatment-approaches-16868?t=229)

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