# Neurofibromatosis — GCMD Library living collection

Experts: Dr. Jill Knepprath

Updated: n/a · 1 episodes · 11 cited statements

## Episodes
### Evidence & Research
- [Malignant peripheral nerve sheath tumors: a report from Children’s Oncology Group study ARST0332](https://library.globalcastmd.com/watch/malignant-peripheral-nerve-sheath-tumors-a-report-from-children-s-oncology-group-study-arst0332-11726) — video · 1:11 · [machine version](https://library.globalcastmd.com/watch/malignant-peripheral-nerve-sheath-tumors-a-report-from-children-s-oncology-group-study-arst0332-11726.md)

## Chapters
- [0:00](https://library.globalcastmd.com/watch/malignant-peripheral-nerve-sheath-tumors-a-report-from-children-s-oncology-group-study-arst0332-11726?t=0) Introduction and study context (Ep 1)
- [0:22](https://library.globalcastmd.com/watch/malignant-peripheral-nerve-sheath-tumors-a-report-from-children-s-oncology-group-study-arst0332-11726?t=22) Study design and treatment arms (Ep 1)
- [0:34](https://library.globalcastmd.com/watch/malignant-peripheral-nerve-sheath-tumors-a-report-from-children-s-oncology-group-study-arst0332-11726?t=34) Outcomes and clinical implications (Ep 1)

## Statements
Every statement is attributed, typed, and timestamped; the link is the citation.
- "The Children's Oncology Group published a prospective trial on malignant peripheral nerve sheath tumors in the Journal of the National Cancer Institute in 2025." — Jill Knepprath (clinical) [Ep 1 · 0:11](https://library.globalcastmd.com/watch/malignant-peripheral-nerve-sheath-tumors-a-report-from-children-s-oncology-group-study-arst0332-11726?t=11)
- "Patients were assigned to four treatment groups: observation, adjuvant radiation, adjuvant chemoradiation, and neoadjuvant chemoradiation." — Jill Knepprath (clinical) [Ep 1 · 0:24](https://library.globalcastmd.com/watch/malignant-peripheral-nerve-sheath-tumors-a-report-from-children-s-oncology-group-study-arst0332-11726?t=24)
- "Resection has a major influence on survival for patients with malignant peripheral nerve sheath tumors." — Jill Knepprath (clinical) [Ep 1 · 0:35](https://library.globalcastmd.com/watch/malignant-peripheral-nerve-sheath-tumors-a-report-from-children-s-oncology-group-study-arst0332-11726?t=35)
- "Female patients with malignant peripheral nerve sheath tumors had improved outcomes." — Jill Knepprath (epidemiological) [Ep 1 · 0:40](https://library.globalcastmd.com/watch/malignant-peripheral-nerve-sheath-tumors-a-report-from-children-s-oncology-group-study-arst0332-11726?t=40)
- "Patients without metastatic disease had improved outcomes." — Jill Knepprath (clinical) [Ep 1 · 0:40](https://library.globalcastmd.com/watch/malignant-peripheral-nerve-sheath-tumors-a-report-from-children-s-oncology-group-study-arst0332-11726?t=40)
- "Low-risk patients had improved outcomes." — Jill Knepprath (clinical) [Ep 1 · 0:40](https://library.globalcastmd.com/watch/malignant-peripheral-nerve-sheath-tumors-a-report-from-children-s-oncology-group-study-arst0332-11726?t=40)
- "In patients receiving neoadjuvant therapy, 23% showed a response." — Jill Knepprath (clinical) [Ep 1 · 0:46](https://library.globalcastmd.com/watch/malignant-peripheral-nerve-sheath-tumors-a-report-from-children-s-oncology-group-study-arst0332-11726?t=46)
- "In patients receiving neoadjuvant therapy, 45% were stable." — Jill Knepprath (clinical) [Ep 1 · 0:46](https://library.globalcastmd.com/watch/malignant-peripheral-nerve-sheath-tumors-a-report-from-children-s-oncology-group-study-arst0332-11726?t=46)
- "In patients receiving neoadjuvant therapy, 32% had progressive disease." — Jill Knepprath (clinical) [Ep 1 · 0:46](https://library.globalcastmd.com/watch/malignant-peripheral-nerve-sheath-tumors-a-report-from-children-s-oncology-group-study-arst0332-11726?t=46)
- "There was no difference in survival based on the response to neoadjuvant therapy among patients who went on to have resection." — Jill Knepprath (clinical) [Ep 1 · 0:59](https://library.globalcastmd.com/watch/malignant-peripheral-nerve-sheath-tumors-a-report-from-children-s-oncology-group-study-arst0332-11726?t=59)
- "Resection should be done for patients with malignant peripheral nerve sheath tumors whenever possible, even if they show a good response to chemoradiation." — Jill Knepprath (guideline) [Ep 1 · 1:03](https://library.globalcastmd.com/watch/malignant-peripheral-nerve-sheath-tumors-a-report-from-children-s-oncology-group-study-arst0332-11726?t=63)

## Changelog
- Aug 31: 1 doctors auto-found from episode dossiers
- Aug 30: 1 doctors auto-found from episode dossiers
- Aug 30: 1 doctors auto-found from episode dossiers
- Aug 29: 1 doctors auto-found from episode dossiers
- Aug 29: 1 doctors auto-found from episode dossiers
- Aug 29: Collection generated from campaign corpus: 1 items, 1 dossiers, summaries for 4 audience(s)
- Aug 29: Collection reviewed and published
- Aug 29: Collection generated from campaign corpus: 1 items, 1 dossiers, summaries for 4 audience(s)

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