Translational Research in Biliary Atresia: News from Mice and Men
dx.doi.org shows its articles on its own site.
Read the article on dx.doi.org ↗Article · Aug 2019 · 1 min read
In brief
In brief
This review examines animal models of biliary atresia and the challenges in translating preclinical findings to clinical practice. Despite decades of research using various animal models, the gap between basic science discoveries and bedside application remains significant for this leading cause of pediatric liver transplantation.
Written by the GCMD Library team from the article.
Biliary atresia (BA) is a fibro-obliterative cholangiopathy of unknown etiology. While Kasai portoenterostomy achieves temporary biliary drainage in some cases, BA remains the most common indication for liver transplantation during childhood. During the last few decades, observations on BA, like cholestatic diseases in animals and the introduction of different animal models for BA, have not achieved the anticipated results, and we are still not able to translate the basic research to the patient's bedside. This article presents a review of the literature on available BA animal models and gives a glimpse of future developments.