Social Determinants of Health Influence on Survival in Wilms Tumor, Neuroblastoma, and Hepatoblastoma
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Read the article on pubmed.ncbi.nlm.nih.gov ↗Article · Jan 2025 · 1 min read
In brief
In brief
National database study of over 12,000 pediatric cancer patients reveals that lower socioeconomic status significantly worsens survival in Wilms tumor and neuroblastoma, with Black non-Hispanic children experiencing worse outcomes in neuroblastoma even after controlling for other factors. The analysis demonstrates how social determinants of health create measurable survival disparities in three major childhood solid tumors.
Written by the GCMD Library team from the article.
Statements in this article
The study included 5218 patients with Wilms tumor, 5851 with neuroblastoma, and 1311 with hepatoblastoma from the National Cancer Database between 2004 and 2020.
A socioeconomic status composite score was created by combining quartiles for median household income and percent no high school degree, with higher scores reflecting greater disadvantage.
The racial distribution for Wilms tumor was 59% White non-Hispanic and 18% Black non-Hispanic patients.
The racial distribution for neuroblastoma was 65% White non-Hispanic and 11% Black non-Hispanic patients.
The racial distribution for hepatoblastoma was 55% White non-Hispanic and 11% Black non-Hispanic patients.
Higher socioeconomic status scores were associated with worse survival for Wilms tumor (p = 0.002).
Higher socioeconomic status scores were associated with worse survival for neuroblastoma (p = 0.011).
In children with Wilms tumor, age, higher socioeconomic status score, comorbidities, tumor size, and bilateral and metastatic disease were associated with worse survival in multivariable analysis.
In children with neuroblastoma, age, urbanicity, higher socioeconomic status score, Black non-Hispanic race/ethnicity, tumor size, metastatic disease, and chemotherapy were associated with worse survival in multivariable analysis.
In children with hepatoblastoma, age, comorbidities, and metastatic disease were associated with worse survival in multivariable analysis.