Francesco T. Mangano · Programming parameters affecting seizure reduction in responsive neurostimulation patients at a pediatric center.
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Article1 min read·Published Nov 2026

Programming parameters affecting seizure reduction in responsive neurostimulation patients at a pediatric center.

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Article · Nov 2026 · 1 min read

In brief

In brief

This study examines how programming parameters in responsive neurostimulation (RNS) devices affect seizure reduction outcomes in pediatric drug-resistant epilepsy patients. Researchers analyzed charge density differences between cortical and thalamic targets to identify optimal settings for achieving >50% seizure reduction.

Written by the GCMD Library team from the article.

Francesco T. Mangano

Responsive neurostimulation (RNS) is an effective treatment for drug-resistant epilepsy, but optimal programming strategies remain undefined in pediatric populations. This study investigates the effect of programming parameter differences on time to > 50% seizure reduction. We aimed to determine the charge density at time of 50% seizure reduction response, based on target (cortical v. thalamic). A…

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