Francesco T. Mangano · Predictors of response to vagus nerve stimulation in childhood-onset medically refractory epilepsy.
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Article1 min read·Published Nov 2026

Predictors of response to vagus nerve stimulation in childhood-onset medically refractory epilepsy.

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Article · Nov 2026 · 1 min read

In brief

In brief

This retrospective study identifies clinical predictors of vagus nerve stimulation efficacy in children with medically refractory epilepsy. Analysis of patients receiving VNS implants between 2006-2011 showed 67.4% response rate, with outcomes measured using standardized ILAE seizure frequency scales.

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Francesco T. Mangano

This study explored predictors of response to vagus nerve stimulation in childhood-onset epilepsy. This retrospective chart review included all patients with new vagus nerve stimulator insertion between January 1, 2006, and December 31, 2011. Primary outcome was change in seizure frequency classified on the International League Against Epilepsy scale. Overall, 67.4% (95% confidence limits 53.3%-81…

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  1. 67.4% of patients with childhood-onset medically refractory epilepsy showed response to vagus nerve stimulation (95% confidence limits 53.3%-81%).

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