Predictors for surgical intervention and surgical outcomes in neonates with cystic fibrosis
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In brief
In brief
Retrospective study of 120 CF neonates identifies prematurity and low birthweight as key predictors for meconium ileus requiring surgery, while CF genotype and prenatal echogenic bowel were not predictive. Surgical patients faced prolonged NICU stays (median 34.5 days) and extended TPN dependence, with nearly one-third requiring intestinal atresia repair.
Written by the GCMD Library team from the article.
Background/Purpose
To identify prenatal and perinatal predictors of surgery and describe surgical findings/outcomes of neonates with Meconium Ileus (MI) secondary to Cystic Fibrosis (CF).
Methods
Potential risk factors (prenatal bowel echogenicity, CF genotype, birthweight, prematurity and sex) for MI and surgery were examined in a retrospective cohort of neonates with CF presenting to a tertiary center between 1997 and 2015. Following univariable analysis, predictors of MI and surgery were determined using multivariable logistic regression. For surgical patients, detailed operative findings and outcomes were examined.
Results
MI was diagnosed in 26/120 (21.7%) neonates with CF and 19/26 (73.0%) required surgery. Prematurity was significantly associated with increased risk of MI and operative intervention (p-value 0.022 and p-value 0.016 respectively); lower birthweight was associated with operative intervention (p-value 0.039); genotype and echogenic bowel were associated with neither. Surgical data were available for 17/19 patients; median age at surgery was 2 days (IQR1–3), 4/17 had an atresia and 6/17 received an ostomy. Median NICU and hospital stays were 34.5 and 70 days while median time on TPN and time to ostomy reversal were 28.5 and 97 days, respectively.
Conclusions
In patients with CF, prematurity and lower birthweight were identified as risk factors for meconium ileus and need for surgery. Specific genotypes and echogenic bowel were not predictors of either.
Level of evidence
Level III.