Francesco T. Mangano · Neuropsychological outcomes after resection of cortical sites with visual naming associated electrocorticographic high-gamma modulation.
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Article1 min read·Published Nov 2026

Neuropsychological outcomes after resection of cortical sites with visual naming associated electrocorticographic high-gamma modulation.

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Article · Nov 2026 · 1 min read

In brief

In brief

This prospective study validates high-gamma modulation as a functional language mapping tool by comparing neuropsychological outcomes in epilepsy surgery patients who had cortical sites with visual naming-associated HGM resected versus preserved. Results demonstrate that resection of HGM-positive language sites correlates with measurable postoperative language deficits at one-year follow-up.

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Francesco T. Mangano

Language mapping with high-gamma modulation (HGM) has compared well with electrical cortical stimulation mapping (ESM). However, there is limited prospective data about its functional validity. We compared changes in neuropsychological evaluation (NPE) performed before and 1-year after epilepsy surgery, between patients with/without resection of cortical sites showing HGM during a visual naming ta…

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